CORRELATION BETWEEN DOPPLER PARAMETERS AND RENAL CORTICAL FIBROSIS IN LUPUS NEPHRITIS: A PRELIMINARY OBSERVATION
CORRELATION BETWEEN DOPPLER PARAMETERS AND RENAL CORTICAL FIBROSIS IN LUPUS NEPHRITIS: A PRELIMINARY OBSERVATION
复制标题
DOI：
10.1016/j.ultrasmedbio.2012.10.009
复制
发表时间：
2013-02-01
影响因子：
2.9
通讯作者：
Min, Robert
中科院分区：
文献类型：
--
作者：
Gao, Jing;Chevalier, James;Min, Robert
为探讨狼疮性肾炎(LN)肾血流参数与肾皮质纤维化的关系，我们对24例LN患者进行了肾脏彩色多普勒超声检查和肾活检。测量经角度校正的肾主动脉和叶间动脉的峰值血流速度(PSV)、舒张期末期血流速度(EDV)和阻力指数(RI)。对肾活检标本进行组织病理学分析，比较叶间动脉与主肾动脉的多普勒参数及PSV、EDV比值。根据肾皮质纤维化程度将24例LN分为轻度(6%~25%)肾皮质纤维化(13例)和中度(26%~50%)肾皮质纤维化(11例)两组。采用独立样本双尾t检验分析两组间PSV、EDV、RI的差异。分析受试者的操作特性，以评估叶间动脉PSV和EDV预测中度肾皮质纤维化的准确性。结果显示，中度肾皮质纤维化组的PSV和EDV均低于轻度肾皮质纤维化组。两组间叶间动脉的PSV、EDV，肾动脉主干的EDV、RI，以及叶间动脉与主肾动脉的PSV、EDV比值差异有统计学意义(均P<0.05)。PSV和EDV预测26%肾皮质纤维化的受试者工作特征曲线下面积分别为0.96和0.90。鉴别>；26%肾皮质纤维化的最佳临界值
To assess the relationship between renal Doppler parameters and renal cortical fibrosis in lupus nephritis (LN), we retrospectively reviewed 24 patients with LN underwent both renal color Doppler sonography and renal biopsy. The angle-corrected Doppler parameters, including peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) at the main and interlobar renal arteries were measured. The Doppler parameters and PSV and EDV ratios of the interlobar artery to main renal artery were compared with histopathologic analysis of the kidney biopsy specimen. On the basis of renal cortical fibrosis, the 24 cases of LN were divided into two groups: mild (6%-25%) renal cortex fibrosis (n = 13) and moderate (26%-50%) renal cortex fibrosis (n = 11). An independent-samples two tailed t test was used to statistically analyze the differences in PSV, EDV and RI between the two groups. Receiver operating characteristic was analyzed for assessing the accuracy of interlobar artery PSV and EDV in predicting moderate renal cortical fibrosis. In our result, both PSV and EDV in moderate renal cortex fibrosis were lower than that in mild renal cortex fibrosis. There were statistically significant differences in PSV and EDV at the interlobar artery, EDV and RI at the main renal artery, and PSV and EDV ratios of the interlobar artery to main renal artery between the two groups (all p < 0.05). The area under receiver operating characteristic curves of PSV and EDV for predicting >26% renal cortical fibrosis was 0.96 and 0.90, respectively. The optimal cutoff values for differentiating >26% renal cortical fibrosis from those