Porocytosis: a transient pore array secretes the neurotransmitter packet.
Porocytosis: a transient pore array secretes the neurotransmitter packet.
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孔细胞作用：瞬时孔阵列分泌神经递质包。
DOI：
10.1002/ar.b.20051
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Pappas,GeorgeD
中科院分区：
文献类型：
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作者：
Kriebel,MahlonE;Keller,Bruce;Silver,RobertB;Pappas,GeorgeD
胞孔假说是基于突触囊泡的排列性质，突触囊泡形成分泌的解剖功能单位。突触前和突触后的受体阵列形成了一个突触粒，它是传递的单位。由动作电位触发的钙离子的瞬时增加激活阵列的所有孔以脉冲发射器。该阵列确保传输，同时允许频率依赖的分泌量。因此，分泌量是可变的，这允许可塑性。来自阵列的分泌物具有立即突触可塑性的性质，而阵列大小的变化将改变突触强度。阵列的鲁棒性确保了传输的保真度，传输的频率依赖性动态特征给出了立即可塑性的性质;并且，阵列大小的变化产生突触强度的变化以获得长期可靠性。Anat Rec（Part B：New Anat）282 B：38-41，2005年。© 2005 Wiley‐利斯公司
The porocytosis hypothesis is based on the arrayed nature of synaptic vesicles which forms the anatomical functional unit of secretion. The presynaptic array and the postsynaptic array of receptors form a synaptomere which is the unit of transmission. A transient increase in calcium ions, triggered by an action potential, activates all pores of the array to pulse transmitter. The array insures transmission while permitting a frequency dependent amount of secretion. Therefore the amount of secretion is variable which permits plasticity. Secretion from the array has the property of immediate synaptic plasticity whereas a change in array size would change synaptic strength. The robust nature of the array insures fidelity of transmission, a frequency dependent dynamic signature of transmission giving the property of immediate plasticity; and, a change in array size yields a change in synaptic strength for long term reliability. Anat Rec (Part B: New Anat) 282B:38–41, 2005. © 2005 Wiley‐Liss, Inc.