Preconditioning of umbilical cord‐derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis
Preconditioning of umbilical cord‐derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis
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DOI：
10.1111/cpr.12546
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发表时间：
2018-12
影响因子：
8.5
通讯作者：
Jun Zheng;Hui Li;Liying He;Yiming Huang;Jianye Cai;Liang Chen;Chaorong Zhou;Hongyuan Fu;Tongyu Lu;Yingcai Zhang;Jia Yao;Yang Yang-Yang
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文献类型：
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作者：
Jun Zheng;Hui Li;Liying He;Yiming Huang;Jianye Cai;Liang Chen;Chaorong Zhou;Hongyuan Fu;Tongyu Lu;Yingcai Zhang;Jia Yao;Yang Yang-Yang
输注脐带间充质干细胞(UC-MSCs)是治疗多种肝病的一种新策略。然而，UC-MSCs的治疗效果有限，因为只有少数UC-MSCs向受损区域迁移。在本研究中，我们观察了自噬对UC-MSCs在体外和肝脏缺血/再灌注(I/R)损伤模型中迁移的影响。
Transfusion of umbilical cord‐derived mesenchymal stem cells (UC‐MSCs) is a novel strategy for treatment of various liver diseases. However, the therapeutic effect of UC‐MSCs is limited because only a few UC‐MSCs migrate towards the damaged regions. In this study, we observed the effects of autophagy on the migration of UC‐MSCs in vitro and in a model of liver ischaemia/reperfusion (I/R) injury.