FIBROGENIC CYTOKINES - THE ROLE OF IMMUNE MEDIATORS IN THE DEVELOPMENT OF SCAR TISSUE
FIBROGENIC CYTOKINES - THE ROLE OF IMMUNE MEDIATORS IN THE DEVELOPMENT OF SCAR TISSUE
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DOI：
10.1016/0167-5699(91)90107-5
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
KOVACS, EJ
中科院分区：
文献类型：
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作者：
KOVACS, EJ
各种以纤维化为特征的疾病都有共同的特征，包括成纤维细胞的增殖和细胞外基质的沉积。纤维化通常以白细胞浸润的炎症反应开始，随后是细胞因子的细化。Elizabeth J. Kovacs认为，这些介质的异常产生维持了结缔组织的积累，从而导致组织结构和功能的永久性改变。
A variety of diseases that are characterized by fibrosis share common features including the proliferation of fibroblasts and the deposition of extracellular matrix. Fibrosis often begins as an inflammatory reaction with leukocyte infiltration followed by the elaboration of cytokines. Here, Elizabeth J. Kovacs argues that the aberrant production of these mediators sustains the connective tissue accumulation that results in permanent alteration in tissue structure and function.