Thrombostatin Inhibits Cyclic Flow Variations in Stenosed Canine Coronary Arteries
Thrombostatin Inhibits Cyclic Flow Variations in Stenosed Canine Coronary Arteries
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凝血酶抑制素抑制狭窄犬冠状动脉的循环血流变化
DOI：
10.1055/s-0037-1616065
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发表时间：
2001
影响因子：
6.7
通讯作者：
S. Werns
中科院分区：
文献类型：
--
作者：
A. Hasan;A. Schmaier;M. Warnock;D. Normolle;E. Driscoll;B. Lucchesi;S. Werns
Summary Thrombostatins are a group of compounds based upon a breakdown product of bradykinin, RPPGF. They inhibit -thrombin-induced platelet activation by binding to protease activated receptor 1 and, at a lower affinity, by interacting with thrombin’s active site. After a single intravenous infusion of MAP4-RPPGF (11.58 mg/kg), its t½α was 4.5 min with a clearance of 2.0 ml/min. MAP4-RPPGF administration had a sustained antiplatelet effect, preventing γ-thrombin-induced (12.5 nM) platelet activation for 4 h. Its antiplatelet effect summated with that of aspirin and/or clopidogrel. MAP4-RPPGF was compared with aspirin and clopidogrel in the Folts model of coronary artery thrombosis. Dogs were randomized to 3 treatment groups: aspirin 1.14 mg/kg i. v., clopidogrel 0.5 mg/kg i. v., or MAP4-RPPGF 0.77 mg/kg i. v. Cyclic flow variations (CFV) were recorded in 5 untreated dogs hourly for 3 successive hours and for 1 h before (all groups >11 CFV/h), and for 2 h after drug infusion in each of the 3 treatment groups. After 1 h drug treatment, all groups of animals had <6 CFV/h; after 2 h treatment, all had <1 CFV/h. All agents significantly reduced CFV from control at each hour, but none was significantly better than any other. Thrombostatin was as effective as aspirin or clopidogrel in inhibiting coronary artery thrombosis in this canine model.
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DOI：
--
发表时间：
1997-10
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
S. Rebello;H. S. Blank;W. Rote;G. Vlasuk;B. Lucchesi
通讯作者：
S. Rebello;H. S. Blank;W. Rote;G. Vlasuk;B. Lucchesi
影响因子：
37.8
作者：
Hasan, AAK;Amenta, S;Schmaier, AH
通讯作者：
Schmaier, AH
激肽原的结构域 3 包含一个细胞结合位点和一个修饰血小板凝血酶活化的位点。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Jiang,YP;Muller-Esterl,W;Schmaier,AH
通讯作者：
Schmaier,AH
实验动物模型中血小板糖蛋白 IIb/IIIa 受体单克隆抗体的抗血栓作用。
影响因子：
20.3
作者：
Coller,BS;Folts,JD;Scudder,LE;Smith,SR
通讯作者：
Smith,SR
ADP 在体内狭窄和内皮损伤的犬冠状动脉中介导血小板聚集和循环血流变化中发挥重要作用。
影响因子：
20.1
作者：
Yao,SK;Ober,JC;McNatt,J;Benedict,CR;Rosolowsky,M;Anderson,HV;Cui,K;Maffrand,JP;Campbell,WB;Buja,LM
通讯作者：
Buja,LM