The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions.
The lipidic particle as an intermediate structure in membrane fusion processes and bilayer to hexagonal HII transitions.
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脂质颗粒作为膜融合过程和双层到六边形 HII 转变的中间结构。
DOI：
10.1016/0005-2736(80)90465-4
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
B. de Kruijff
中科院分区：
文献类型：
--
作者：
A. Verkleij;C. V. van Echteld;W. J. Gerritsen;P. Cullis;B. de Kruijff
由磷脂酰乙醇胺/磷脂酰胆碱/胆固醇（3:1:2）混合物组成的单层小泡在温度从0℃升高到50℃时融合形成大的多层小泡。这一事件与融合部位脂质颗粒的出现有关，与融合过程中作为中间结构的作用一致。此外，对于Mn2+存在下的磷脂酰胆碱/心磷脂（1:1）脂质体，脂质颗粒与六方（HII）相之间存在直接关系，这表明脂质颗粒也可以作为双层和六方（HII）结构之间的中介。
Small unilamellar vesicles comprised of a mixture of phosphatidylethanolamine/phosphatidylcholine/cholesterol (3 : 1 : 2) fuse to form large multilamellar vesicles on increasing the temperature from 0 to 50°C. This event is associated with the appearance of lipidic particles at the fusion sites, consistent with a role as intermediary structures during the fusion process. Further, for phosphatidylcholine/cardiolipin (1 : 1) liposomes in the presence of Mn2+a direct relationship between lipidic particles and the hexagonal (HII) phase is demonstrated which suggests that lipidic particles can also occur as intermediaries between bilayer and hexagonal (HII) structures.