Implantable Cisplatin Synthesis Microdevice for Regional Chemotherapy
Implantable Cisplatin Synthesis Microdevice for Regional Chemotherapy
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DOI：
10.1002/adhm.202001582
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发表时间：
2020-12-16
影响因子：
10
通讯作者：
Kim, Albert
中科院分区：
文献类型：
--
作者：
Campbell, Rebecca;Shim, Hyunji;Kim, Albert
顺铂是1978年获得美国食品和药物管理局（FDA）批准的第一种铂类化疗药物，广泛用于多种癌症。然而，全身给药带来的痛苦副作用是顺铂不可避免的局限性。一个可能的解决方案是使用各种药物输送系统的局部化疗，这可以减少全身毒性并增加药物在肿瘤中的积累。本文介绍了一种米粒大小、超声驱动、可植入的原位合成顺铂的微型装置。该微型装置在超声照射（400 mW cm(-2)）下1小时内产生0.7 mg顺铂。利用体外小鼠乳腺癌细胞和离体肝组织对微装置合成的顺铂的效果进行了评估。结果表明，在体外和离体实验中，微装置介导的顺铂递送的细胞毒活性都明显更高。总的来说，提出的顺铂合成微装置代表了局部化疗的一个强有力的替代治疗选择
Cisplatin, the first platinum chemotherapy agent to obtain Food and Drug Administration (FDA) approval in 1978, is widely used for a number of cancers. However, the painful side effects stemming from systemic delivery are the inevitable limitation of cisplatin. A possible solution is regional chemotherapy using various drug delivery systems, which reduces the systemic toxicity and increases drug accumulation in the tumor. In this paper, a rice-grain sized, ultrasonically powered, and implantable microdevice that can synthesize cisplatin in situ is presented. The microdevice produces 0.7 mg of cisplatin within 1 h under ultrasonic irradiation (400 mW cm(-2)). The effect of the microdevice-synthesized cisplatin is evaluated using in vitro murine breast cancer cells and ex vivo liver tissue. The results suggest that cytotoxic activities of the microdevice-mediated cisplatin delivery are significantly higher in both in vitro and ex vivo experiments. Overall, the proposed cisplatin synthesis microdevice represents a strong alternative treatment option for regional chemotherapy