Injectable hydrogels for bone and cartilage repair
Injectable hydrogels for bone and cartilage repair
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DOI：
10.1088/1748-6041/7/2/024105
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发表时间：
2012-04-01
影响因子：
4
通讯作者：
Nair, Lakshmi S.
中科院分区：
文献类型：
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作者：
Amini, Ashley A.;Nair, Lakshmi S.
可注射的原位可交联凝胶在临床上是非常理想的，因为它们可以使用内窥镜或经皮手术经由微创方式引入体内。目前正在开发几种亲水性聚合物系统，其响应于刺激，例如光、温度、pH、离子浓度以及可以经历化学反应以形成交联基质的那些。本文讨论了水凝胶作为支架材料模拟天然骨和软骨细胞外基质的应用。还介绍了用于水凝胶制备的各种凝胶化方法及其作为骨和软骨再生的可注射细胞和蛋白质递送载体的应用。
Injectable in situ crosslinkable gels are highly desirable clinically as they can be introduced into a body via a minimally invasive manner using endoscopic or percutaneous procedures. Several hydrophilic polymeric systems that respond to stimuli such as light, temperature, pH, ionic concentration as well as those that can undergo chemical reactions to form crosslinked matrices are currently under development. This paper discusses the applications of hydrogels as scaffolds to mimic the native extracellular matrix of bone and cartilage. A comprehensive description of various gelation methods used in hydrogel preparation and their application as injectable cell and protein delivery vehicle for bone and cartilage regeneration is also presented.