Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response
Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response
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高急性炎症反应小鼠选择过程中粒细胞生成、趋化活性和中性粒细胞凋亡的趋同变化
DOI：
10.1189/jlb.0103039
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发表时间：
2003
影响因子：
5.5
通讯作者：
M. Seman
中科院分区：
文献类型：
--
作者：
O. Ribeiro;D. Maria;S. Adriouch;Séverine Pechberty;W. Cabrera;J. Morisset;O. Ibañez;M. Seman
研究了AIRMX和AIRMIN两个基因选择的急性炎症反应(AIR)高或低小鼠的中性粒细胞动态平衡，并与未选择的BALB/c小鼠进行比较。成熟的中性粒细胞表型和功能在三个品系的小鼠中表现相似。然而，在Airmax动物中发现了一种前所未有的表型，其特征是骨髓(BM)中产生高中性粒细胞，血液中有大量中性粒细胞，丙烯酰胺诱导的炎性渗出物中有高浓度的趋化物质，局部浸润性中性粒细胞对自发凋亡的抵抗力增强。在体外，中性粒细胞和嗜酸性粒细胞的骨髓生成伴随着CD131抗体评估的细胞因子受体异常高的上调，CD131与白细胞介素3、白细胞介素5和粒细胞巨噬细胞集落刺激因子结合共同的β受体链。对全反式维甲酸的反应也观察到中性粒细胞加速成熟。可以提出几个候选基因来解释这种表型。然而，更重要的是，这些结果强调，基于空气程度的遗传选择，从八个近亲交配的小鼠品系杂交产生的创始种群开始，表现出持续的炎症反应，可以导致影响中性粒细胞稳态的等位基因的收敛选择。类似的基因组合可能发生在人类身上，对炎症性或传染性疾病和癌症的易感性有重要影响。
Neutrophil homeostasis was investigated in two mouse lines, AIRmax and AIRmin, genetically selected for high or low acute inflammatory response (AIR) and compared with unselected BALB/c mice. Mature neutrophil phenotype and functions appeared similar in the three mouse lines. However, an unprecedented phenotype was revealed in AIRmax animals characterized by a high neutrophil production in bone marrow (BM), a high number of neutrophils in blood, a high concentration of chemotactic agents in acrylamide‐induced inflammatory exudates, and an increased resistance of locally infiltrated neutrophils to spontaneous apoptosis. In vitro, BM production of neutrophils and eosinophils was accompanied by an unusual high up‐regulation of cytokine receptors as assessed by antibodies to CD131, which bind the common β chain of receptors to interleukin (IL)‐3, IL‐5, and granulocyte macrophage‐colony stimulating factor. An accelerated neutrophil maturation was also observed in response to all‐trans retinoic acid. Several candidate genes can be proposed to explain this phenotype. Yet, more importantly, the results underline that genetic selection, based on the degree of AIR and starting from a founding population resulting from the intercross of eight inbred mouse lines, which display a continuous range of inflammatory responses, can lead to the convergent selection of alleles affecting neutrophil homeostasis. Similar gene combinations may occur in the human with important consequences in the susceptibility to inflammatory or infectious diseases and cancer.
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影响因子：
20.3
作者：
Anderson, KL;Smith, KA;Torbett, BE
通讯作者：
Torbett, BE
DOI：
10.1073/pnas.92.21.9565
发表时间：
1995-10-10
影响因子：
11.1
作者：
ROBB, L;DRINKWATER, CC;BEGLEY, CG
通讯作者：
BEGLEY, CG
通过组织蛋白酶 H 生成具有生物活性的补体 (C5) 衍生肽。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Perez,HD;Ohtani,O;Banda,D;Ong,R;Fukuyama,K;Goldstein,IM
通讯作者：
Goldstein,IM
视黄酸诱导的骨髓细胞中 CD38 抗原的表达是通过视黄酸受体-α 介导的。
影响因子：
11.2
作者：
Drach,J;McQueen,T;Engel,H;Andreeff,M;Robertson,KA;Collins,SJ;Malavasi,F;Mehta,K
通讯作者：
Mehta,K
DOI：
10.1152/ajplung.2001.281.5.l1210
发表时间：
2001-11-01
影响因子：
4.9
作者：
Paine, R;Morris, SB;Toews, GB
通讯作者：
Toews, GB