Adiposity, type 2 diabetes, and Alzheimer's disease.
Adiposity, type 2 diabetes, and Alzheimer's disease.
复制标题
肥胖、2 型糖尿病和阿尔茨海默病。
DOI：
10.3233/jad-2009-1022
复制
发表时间：
2009
影响因子：
4
通讯作者：
Gustafson, Deborah R.
中科院分区：
文献类型：
--
作者：
Luchsinger, Jose A.;Gustafson, Deborah R.
关键词：
这篇手稿全面回顾了肥胖症和2型糖尿病(T2D)与阿尔茨海默病(AD)之间的流行病学证据。肥胖和T2D与AD相关的机制可能包括高胰岛素血症、晚期糖化产物、脑血管疾病和脂肪组织代谢产物。中年肥胖症的增加与AD的高风险有关，但关于老年的这种联系的数据是相互矛盾的。多项研究表明，高胰岛素血症是高肥胖症和胰岛素抵抗的结果，也与AD的高风险有关。高胰岛素血症是T2D的危险因素，大量研究表明T2D与更高的AD风险有关。这些关联的含义是，鉴于超重、肥胖、高胰岛素血症和T2D患病率增加的趋势，世界上很大一部分人口可能面临AD风险的增加。然而，这些关联可能为预防和治疗阿尔茨海默病提供了独特的机会。一些预防和治疗T2D的研究目前正在进行或计划进行认知辅助研究。此外，使用胰岛素增敏剂治疗或预防阿尔茨海默病的临床试验正在进行中。
This manuscript provides a comprehensive review of the epidemiologic evidence linking the continuum of adiposity and type 2 diabetes (T2D) with Alzheimer's disease (AD). The mechanisms relating adiposity and T2D to AD may include hyperinsulinemia, advanced products of glycosilation, cerebrovascular disease, and products of adipose tissue metabolism. Elevated adiposity in middle age is related to a higher risk of AD but the data on this association in old age is conflicting. Several studies have shown that hyperinsulinemia, a consequence of higher adiposity and insulin resistance is also related to a higher risk of AD. Hyperinsulinemia is a risk factor for T2D, and numerous studies have shown a relation of T2D with higher AD risk. The implication of these associations is that a large proportion of the world population may be at increased risk of AD given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and T2D. However these associations may present a unique opportunity for prevention and treatment of AD. Several studies in the prevention and treatment of T2D are currently conducting or have planned cognition ancillary studies. In addition, clinical trials using insulin sensitizers in the treatment or prevention of AD are under way.