Human and Veterinary Vaccines for Lyme Disease.
Human and Veterinary Vaccines for Lyme Disease.
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莱姆病的人类和兽医疫苗。
DOI：
10.21775/cimb.042.191
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发表时间：
2021
影响因子：
3.1
通讯作者：
Marconi RT
中科院分区：
文献类型：
--
作者：
O'Bier NS;Hatke AL;Camire AC;Marconi RT
莱姆病（LD）是一种新兴的人畜共患感染，在北美、欧洲和亚洲的发病率正在上升。随着安全有效疫苗的开发，LD有可能被预防。疫苗接种为降低感染风险提供了一种具有成本效益和安全的方法。虽然LD疫苗已广泛用于兽医学，但它们不能作为人类的预防工具。开发有效疫苗的核心是了解LD的地方性循环，伯氏疏螺旋体对环境变量的差异基因表达，以及导致这种使人衰弱的疾病的独特细菌的遗传和抗原多样性。在这里，我们回顾了这些领域，因为它们与过去和现在开发人类、兽医和水库靶向LD疫苗的努力有关。此外，我们还简要概述了应与疫苗接种结合使用的其他预防措施。
Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the development of effective vaccines is an understanding of the enzootic cycle of LD, differential gene expression of Borrelia burgdorferi in response to environmental variables, and the genetic and antigenic diversity of the unique bacteria that cause this debilitating disease. Here we review these areas as they pertain to past and present efforts to develop human, veterinary, and reservoir targeting LD vaccines. In addition, we offer a brief overview of additional preventative measures that should employed in conjunction with vaccination.
影响因子：
6.7
作者：
Beernink PT;Shaughnessy J;Pajon R;Braga EM;Ram S;Granoff DM
通讯作者：
Granoff DM