Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
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作者：
Leucine rich repeat kinase 2 (LRRK2) mutations are a common cause of Parkinson’s disease (PD). Here, we identify inhibitors of LRRK2 kinase, which are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of PD.
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影响因子：
6.1
作者：
Greggio, Elisa;Jain, Shushant;Cookson, Mark R.
通讯作者：
Cookson, Mark R.
DOI：
10.1073/pnas.0508052102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Smith, WW;Pei, Z;Ross, CA
通讯作者：
Ross, CA
影响因子：
11.4
作者：
Imai, Yuzuru;Gehrke, Stephan;Lu, Bingwei
通讯作者：
Lu, Bingwei
影响因子：
4.8
作者：
Leclerc, S;Garnier, M;Meijer, L
通讯作者：
Meijer, L
DOI：
10.1016/j.bbrc.2009.04.098
发表时间：
2009-06-26
影响因子：
3.1
作者：
Reichling, Laurie J.;Riddle, Steven M.
通讯作者：
Riddle, Steven M.