Controlled and targeted delivery of diclofenac sodium to the intestine from pH-Responsive chitosan/poly(vinyl alcohol) interpenetrating polymeric network hydrogels
Controlled and targeted delivery of diclofenac sodium to the intestine from pH-Responsive chitosan/poly(vinyl alcohol) interpenetrating polymeric network hydrogels
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DOI：
10.1134/s0965545x16020048
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发表时间：
2016-03-01
影响因子：
1
通讯作者：
Subuddhi, Usharani
中科院分区：
文献类型：
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作者：
Das, Subhraseema;Subuddhi, Usharani
探讨了由壳聚糖和聚乙烯醇组成的pH响应性水凝胶用于双氯芬酸钠（DS）的肠道控释。为了调节药物的释放，预先形成的固体包合物的DS与-环糊精（-CD）加入到水凝胶。药物在模拟胃液中释放量可忽略不计，在肠液中持续释放。初步动力学研究表明，药物释放遵循受-CD影响的异常转运机制。这些水凝胶的pH特异性释放行为表明它们是DS口服控释至肠道的理想候选物。
pH-Responsive hydrogels comprised of chitosan and poly(vinyl alcohol) were explored for the controlled delivery of diclofenac sodium (DS) to the intestine. To regulate the drug delivery, preformed solid inclusion complex of DS with -cyclodextrin (-CD) was added into the hydrogels. Negligible drug release was observed in the simulated gastric fluid and sustained release in the intestinal fluid. The preliminary kinetics revealed that the drug release follows anomalous transport mechanism which is influenced by the presence of -CD. The pH-specific release behavior of these hydrogels suggests them to be ideal candidates for oral controlled delivery of DS to the intestine.