Epithelial Sodium and Chloride Channels and Asthma.
Epithelial Sodium and Chloride Channels and Asthma.
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上皮钠通道和氯通道与哮喘
DOI：
10.4103/0366-6999.162494
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发表时间：
2015-08-20
影响因子：
6.1
通讯作者：
Ji HL
中科院分区：
文献类型：
--
作者：
Wang W;Ji HL
目的：探讨上皮钠/氯离子通道（ENaC/Cl）与哮喘发病机制及临床表现的关系。数据来源：本综述分析的数据来自期刊数据库，主要是PubMed和Google Scholar，从1980年到2015年的英文文章。文献检索中使用的术语为：（1）ENaC;囊性纤维化（CF）跨膜传导调节因子（CFTR）;哮喘/哮喘，（2）ENaC/钠盐; CF;哮喘/哮喘，（3）CFTR/氯离子通道;哮喘/哮喘，（4）ENaC/钠通道/scnn 1a/scnn 1b/scnn 1g/scnn 1d/阿米洛利敏感/阿米洛利可耐受钠通道/钠盐;哮喘/哮喘，肺/肺/呼吸/气管/肺泡，和（5）CFTR; CF;哮喘/哮喘（ti）。研究选择：这些研究包括随机对照试验或过去25年（1990年至2015年）内与ENaC/氯离子通道相关的哮喘发病机制和临床表现的研究。作者还回顾了从个体研究中获得的涉及慢性阻塞性肺疾病和CF的数据。结果：气道表面液体脱水可引起气道炎症和阻塞。ENaC和CFTR与气道黏膜纤毛清除率密切相关。离子转运蛋白可能在哮喘急性发作的发病机制中起关键作用。结论：离子通道已成为许多研究的中心，旨在了解哮喘的病理生理机制或确定更好地控制疾病的治疗靶点。
Objective:To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel. Data Sources:The data analyzed in this review were the English articles from 1980 to 2015 from journal databases, primarily PubMed and Google Scholar. The terms used in the literature search were: (1) ENaCs; cystic fibrosis (CF) transmembrane conductance regulator (CFTR); asthma/asthmatic, (2) ENaC/sodium salt; CF; asthma/asthmatic, (3) CFTR/chlorine ion channels; asthma/asthmatic, (4) ENaC/sodium channel/scnn1a/scnn1b/scnn1g/scnn1d/amiloride-sensitive/amiloride-inhibtable sodium channels/sodium salt; asthma/asthmatic, lung/pulmonary/respiratory/tracheal/alveolar, and (5) CFTR; CF; asthma/asthmatic (ti). Study Selection:These studies included randomized controlled trials or studies covering asthma pathogenesis and clinical manifestations related to ENaC/chlorine ion channels within the last 25 years (from 1990 to 2015). The data involving chronic obstructive pulmonary disease and CF obtained from individual studies were also reviewed by the authors. Results:Airway surface liquid dehydration can cause airway inflammation and obstruction. ENaC and CFTR are closely related to the airway mucociliary clearance. Ion transporters may play a critical role in pathogenesis of asthmatic exacerbations. Conclusions:Ion channels have been the center of many studies aiming to understand asthmatic pathophysiological mechanisms or to identify therapeutic targets for better control of the disease.
影响因子：
2.5
作者：
Shimko MJ;Zaccone EJ;Thompson JA;Schwegler-Berry D;Kashon ML;Fedan JS
通讯作者：
Fedan JS