Increased vascularization in mice overexpressing angiopoietin-1
Increased vascularization in mice overexpressing angiopoietin-1
复制标题
DOI：
10.1126/science.282.5388.468
复制
发表时间：
1998-10-16
期刊：
影响因子：
56.9
通讯作者：
Yancopoulos, GD
中科院分区：
文献类型：
--
作者：
Suri, C;McClain, J;Yancopoulos, GD
血管生成素和血管内皮生长因子（VEGF）家族的成员是被认为主要特异于血管内皮细胞的唯一生长因子。小鼠靶向基因失活研究表明，VEGF是血管发育早期所必需的，血管生成素-1是血管重塑后期所必需的。在这里，它表明，转基因过表达血管生成素-1在小鼠皮肤产生更大，更多，更高度分支的血管。这些结果提高了血管生成素可单独或与VEGF组合用于促进治疗性血管生成的可能性。
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.