Rotamers or Diastereomers? An Overlooked NMR Solution
Rotamers or Diastereomers? An Overlooked NMR Solution
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DOI：
10.1021/jo300734r
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发表时间：
2012-06-01
影响因子：
3.6
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Hu, Dennis X.;Grice, Peter;Ley, Steven V.
分析物溶液中旋转体的存在使H-1核磁共振分析复杂化，特别是当非对映体的存在也是可能的。有机化学家通常通过进行变温核磁共振实验、改变核磁共振溶剂或添加络合剂来解决这个问题。在这里，通过具体的例子，我们说明了简单但被广泛忽视的化学交换核磁共振实验的使用，该实验允许非侵入式快速区分快速平衡的小分子，如旋转体和非平衡非对映体。
The existence of rotamers in a solution of analyte complicates H-1 NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments, changing NMR solvents, or adding complexing agents. Here, with specific examples, we illustrate the use of simple yet widely overlooked chemical-exchange NMR experiments which allow the nonintrusive rapid distinguishment of rapidly equilibrating small molecules such as rotamers from nonequilibrating diastereomers.