The incidence of HIV‐1 infections in village populations of northern Thailand
The incidence of HIV‐1 infections in village populations of northern Thailand
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泰国北部村庄人口的 HIV-1 感染率
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
D. Celentano
中科院分区：
文献类型：
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作者：
K. Nelson;V. Suriyanon;E. Taylor;Tasanai Wongchak;C. Kingkeow;N. Srirak;Chawin Lertsrimongkol;W. Cheewawat;D. Celentano
目的：确定1990年和1992年泰国北部普通流动人口中HIV-1感染的年龄和性别特异性流行率，以及1990年至1992年期间HIV-1感染的发病率。设计：1989年12月至1990年1月在泰国北部清迈省的5个村庄举行了保健展览会，1992年1月又举行了一次。鼓励全村居民参与。向村民提供乙型肝炎病毒（HBV）感染的血清学标志物检测，并向易感个体免费提供HBV疫苗。方法：将两次调查的血清按人口统计学特征（年龄组和性别）进行关联和编码。去除个体标识符，用酶联免疫吸附法检测血清HIV-1抗体，并进行Western blot确认。结果：1990年，1161人中有21人（1.8%）hiv -1血清阳性；男性感染率为3.3%，女性感染率为0.5%。1992年，956人中有44人（4.6%）是hiv -1血清阳性。在两项调查纳入的人群中，女性2年发病率为2.0%，男性为4.1%（年发病率分别为1.0和2.05%）；然而，在14岁以上的男性中，2年发病率为6.3%，而在该年龄段的女性中，2年发病率为1.8%（年发病率分别为3.15%和0.9%）。在男性中，HIV-1感染事件很常见，甚至在50岁以上的人群中也是如此。结论：HIV-1感染在泰国北部半农村地区的成年人群中令人不安地频繁和增加。为了遏制这一流行病的进一步蔓延，将需要针对普通公众，包括农村地区的公众制定公共卫生战略。
Objectives:To determine the age- and sex-specific prevalence of HIV-1 infection in a general ambulatory population in northern Thailand in 1990 and 1992, and the incidence of HIV-1 infections between 1990 and 1992.Design:Health fairs were held in five villages in Chiang Mai province in northern Thailand between December 1989 and January 1990 and again in January 1992. Participation of all village residents was encouraged. Villagers were offered testing for serological markers of hepatitis B virus (HBV) infection and free HBV vaccine was made available to susceptible individuals.Methods:Sera from the two surveys were linked and coded by demographic characteristics (age group and sex). Individual identifiers were removed and the sera tested for HIV-1 antibodies by enzyme-linked immunosorbent assay with Western blot confirmation.Results:In 1990, 21 out of 1161 (1.8%) individuals were HIV-1-seropositive; the infection rates were 3.3% in men and 0.5% in women. In 1992, 44 out of 956 (4.6%) individuals were HIV-1-seropositive. Among people included in both surveys the 2-year incidence was 2.0% in women and 4.1% in men (annual incidence, 1.0 and 2.05%, respectively); however, among men over the age of 14 years the 2-year incidence was 6.3%, whereas among women of this age the 2-year incidence was 1.8% (annual incidence, 3.15 and 0.9%, respectively). Among men, incident HIV-1 infections were common, even among those aged 50 years or more.Conclusions:Infections with HIV-1 are disturbingly frequent and increasing among adult populations in semi-rural areas of northern Thailand. In order to contain further spread of the epidemic public-health strategies targeted to the general public, including those in rural areas, will be needed.