Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury.
Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury.
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脑源性神经营养因子（BDNF）和小分子模拟BDNF治疗创伤性脑损伤的潜力。
DOI：
10.4103/1673-5374.198964
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发表时间：
2017-01
影响因子：
6.1
通讯作者：
Sun D
中科院分区：
文献类型：
--
作者：
Wurzelmann M;Romeika J;Sun D
创伤性脑损伤（TBI）是世界范围内的主要健康问题。原发性机械损伤后，继发性损伤的级联反应往往导致进一步的神经组织损失。到目前为止，还没有治愈方法来挽救受损的神经组织。目前的治疗策略主要针对继发性损伤，侧重于神经保护和神经再生。脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）在促进神经元存活、突触可塑性和神经发生方面具有重要作用。最近，类黄酮7，8-二羟基黄酮（7，8-DHF），一种模拟BDNF功能的小TrkB激动剂，在TBI后促进神经元存活和再生方面显示出与BDNF相似的作用。与BDNF相比，7，8-DHF具有更长的半衰期和更小的分子尺寸，能够穿透血脑屏障，这使得无创临床应用成为可能。本文综述了BDNF/TrkB信号通路的功能以及BDNF和7，8-DHF治疗TBI的研究进展。
Traumatic brain injury (TBI) is a major health problem worldwide. Following primary mechanical insults, a cascade of secondary injuries often leads to further neural tissue loss. Thus far there is no cure to rescue the damaged neural tissue. Current therapeutic strategies primarily target the secondary injuries focusing on neuroprotection and neuroregeneration. The neurotrophin brain-derived neurotrophic factor (BDNF) has significant effect in both aspects, promoting neuronal survival, synaptic plasticity and neurogenesis. Recently, the flavonoid 7,8-dihydroxyflavone (7,8-DHF), a small TrkB agonist that mimics BDNF function, has shown similar effects as BDNF in promoting neuronal survival and regeneration following TBI. Compared to BDNF, 7,8-DHF has a longer half-life and much smaller molecular size, capable of penetrating the blood-brain barrier, which makes it possible for non-invasive clinical application. In this review, we summarize functions of the BDNF/TrkB signaling pathway and studies examining the potential of BDNF and 7,8-DHF as a therapy for TBI.