Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review.
Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review.
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DOI：
10.1371/journal.pone.0069430
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hall AJ
中科院分区：
文献类型：
--
作者：
Shimakawa Y;Yan HJ;Tsuchiya N;Bottomley C;Hall AJ
感染B型肝炎病毒（HBV）时的年龄是慢性HBV感染的已知危险因素。然而，此外，有一些证据表明，感染时的早期年龄进一步增加了原发性肝癌的风险，而不仅仅是与慢性感染风险增加有关。这篇系统性的观察性研究综述评估了慢性HBV感染开始时的年龄与肝硬化、肝细胞癌及其预测因子（包括持续病毒复制和肝损害的指标）之间的关系。该综述包括出生顺序和母亲HBV血清学作为感染年龄的代表。在两个英文数据库（Medline和Embase，截至2012年1月）和两个中文数据库（CNKI和SinoMed，截至2012年9月）中进行电子检索，不受语言限制，通过参考文献列表进行手动检索，共识别出7，077篇论文，其中包括19项研究，涉及21项结局（8项原发性肝癌、1项肝硬化、10项病毒复制和2项肝脏炎症）。一项研究直接检查了纵向队列中感染时的年龄，12项研究评估了母亲血清状态，6项研究了出生顺序。所有研究中的关联方向与我们的假设一致，即感染时年龄越小，除了增加慢性HBV感染的可能性外，还与更差的结局相关。这对控制B型肝炎有意义。
Age at infection with hepatitis B virus (HBV) is a known risk factor for chronic HBV infection. However, in addition, there is some evidence that early age at infection further increases the risk of primary liver cancer beyond its association with increased risk of chronic infection. This systematic review of observational studies assesses the association between age at initiation of chronic HBV infection and liver cirrhosis, hepatocellular carcinoma, and their predictors including indicators of ongoing viral replication and hepatic damage. The review includes birth order and maternal HBV serology as proxies for age at infection. Electronic searches in two English-language (Medline and Embase, until Jan 2012) and two Chinese-language (CNKI and SinoMed, until Sep 2012) databases without language restriction and manual search through reference lists identified 7,077 papers, of which 19 studies of 21 outcomes (8 primary liver cancer, 1 liver cirrhosis, 10 viral replication and 2 liver inflammation) are included. One study directly examined the age at infection in a longitudinal cohort, 12 assessed maternal sero-status and 6 investigated birth order. The direction of associations in all studies was in accordance with our hypothesis that earlier age at infection is associated with worse outcomes in addition to its effect of increasing the probability of chronic HBV infection. This has implications for the control of hepatitis B.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
DOI：
10.1046/j.1440-1746.2003.02976.x
发表时间：
2003-03-01
影响因子：
4.1
作者：
Liaw, YF
通讯作者：
Liaw, YF
影响因子：
--
作者：
Greenwood, M;Yule, GU
通讯作者：
Yule, GU
影响因子：
4.2
作者：
Edmunds, WJ;Medley, GF;Hall, AJ
通讯作者：
Hall, AJ
影响因子：
2.5
作者：
Chu, C. -M.;Liaw, Y. -F.
通讯作者：
Liaw, Y. -F.