Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis.
Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis.
复制标题
白介素 1 受体拮抗剂可抑制三甲基锡诱导的海马坏死初始阶段血浆皮质酮的短暂增加。
作者：
H. Imai;M. Kabuto;M. Takita;N. Kato
脑室注射白细胞介素1受体拮抗剂(IL-1ra)可抑制单次口服三甲基锡(TMT)后3d或4d血浆皮质酮(CORT)水平的短暂升高。而谷氨酸受体拮抗剂(MK801)不影响TMT诱导的皮质醇水平升高。这些结果表明，TMT处理的大鼠下丘脑-垂体-肾上腺皮质轴的这种一过性激活可能部分归因于小胶质细胞产生的IL-1的神经内分泌作用。
The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra). On the other hand, glutamate receptor antagonist (MK801) did not affect the TMT-induced CORT level increase. These results indicate that this transient activation of the hypothalamo-pituitary-adrenocortical axis in TMT-treated rats may be in part attributable to the neuroendocrine effects of IL-1 produced by microglia.