Bidirectional effects on interhemispheric resting‐state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation
Bidirectional effects on interhemispheric resting‐state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation
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DOI：
10.1002/hbm.22300
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Takamitsu Watanabe;R. Hanajima;Y. Shirota;S. Ohminami;R. Tsutsumi;Y. Terao;Y. Ugawa;S. Hirose;Y. Miyashita;S. Konishi;A. Kunimatsu;K. Ohtomo
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作者：
Takamitsu Watanabe;R. Hanajima;Y. Shirota;S. Ohminami;R. Tsutsumi;Y. Terao;Y. Ugawa;S. Hirose;Y. Miyashita;S. Konishi;A. Kunimatsu;K. Ohtomo
最近几项使用功能性磁共振成像（fMRI）的研究表明，重复经颅磁刺激（rTMS）不仅会影响受刺激区域的大脑活动，还会影响受刺激区域与其他远程区域之间的静息态功能连接（RSFC）。然而，这些研究仅证明了兴奋性或抑制性rTMS对RSFC的影响，并没有清楚地表明这两种类型的rTMS的双向作用。在这里，我们通过执行兴奋性和抑制性四脉冲TMS（QPS）来解决这个问题，这被认为对皮层兴奋性产生相对较大和持久的影响。我们发现，兴奋性rTMS（QPS与5毫秒的刺激间的时间间隔）减少了双侧初级运动皮层之间的纵裂RSFC，而抑制性rTMS（QPS与50毫秒的刺激间的时间间隔）增加了纵裂RSFC。这些对RSFC的影响程度与rTMS诱导的对相应肌肉运动诱发电位的影响程度显著相关。QPS的双向效应也被观察到在前额叶和顶叶联合区的刺激。这些发现为兴奋性和抑制性rTMS对RSFC的强大双向作用提供了证据，并提出了QPS可以成为调节RSFC的有力工具的可能性。《脑地图》35：1896-1905，2014年。© 2013威利期刊公司.
Several recent studies using functional magnetic resonance imaging (fMRI) have shown that repetitive transcranial magnetic stimulation (rTMS) affects not only brain activity in stimulated regions but also resting‐state functional connectivity (RSFC) between the stimulated region and other remote regions. However, these studies have only demonstrated an effect of either excitatory or inhibitory rTMS on RSFC, and have not clearly shown the bidirectional effects of both types of rTMS. Here, we addressed this issue by performing excitatory and inhibitory quadripulse TMS (QPS), which is considered to exert relatively large and long‐lasting effects on cortical excitability. We found that excitatory rTMS (QPS with interstimulus intervals of 5 ms) decreased interhemispheric RSFC between bilateral primary motor cortices, whereas inhibitory rTMS (QPS with interstimulus intervals of 50 ms) increased interhemispheric RSFC. The magnitude of these effects on RSFC was significantly correlated with that of rTMS‐induced effects on motor evoked potential from the corresponding muscle. The bidirectional effects of QPS were also observed in the stimulation over prefrontal and parietal association areas. These findings provide evidence for the robust bidirectional effects of excitatory and inhibitory rTMSs on RSFC, and raise a possibility that QPS can be a powerful tool to modulate RSFC. Hum Brain Mapp 35:1896–1905, 2014. © 2013 Wiley Periodicals, Inc.