THE GOLGI-APPARATUS - 2 ORGANELLES IN TANDEM
THE GOLGI-APPARATUS - 2 ORGANELLES IN TANDEM
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DOI：
10.1126/science.7268428
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
ROTHMAN, JE
中科院分区：
文献类型：
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作者：
ROTHMAN, JE
（包括植物和动物在内的真核生物的）高尔基体由不同的顺式和反式区室组成，它们可能依次发挥作用，通过去除逃逸的内质网蛋白质来优化内质网的蛋白质输出。这种优化可能是一个类似于分馏的多阶段过程；由顺式高尔基体组成的扁平囊堆叠可能是这个蒸馏塔中的塔板。由最后1个或2个扁平囊组成的反式高尔基体可能是接收器，它仅从顺式高尔基体收集其最精细的部分，以便随后分配到细胞内的特定位置。
The Golgi apparatus (of eukaryotes including plants and animals) consists of distinct cis and trans compartments that may act sequentially to refine the protein export of the endoplasmic reticulum by removing escaped endoplasmic reticulum proteins. Refinement may be a multistage process akin to fractional distillation; the stack of cisternae comprising the cis Golgi may be the plates in this distillation tower. The trans Golgi, consisting of the last 1 or 2 cisternae, may be the receiver that collects from the cis Golgi only its most refined fraction for later distribution to specific locations throughout the cell.