Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications
Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications
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非编码 RNA 在胃癌中的新作用：发病机制和临床意义
DOI：
10.3748/wjg.v22.i3.1213
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发表时间：
2016-01-21
影响因子：
4.3
通讯作者：
Zhou, Tian-Hua
中科院分区：
文献类型：
--
作者：
Xie, Shan-Shan;Jin, Juan;Zhou, Tian-Hua
胃癌是癌症相关死亡的主要原因。然而，胃癌发生的机制仍不清楚。在过去十年中，非编码 RNA (ncRNA) 与癌症的关联已得到广泛研究。一般来说，ncRNA被分为小ncRNA，包括微小RNA（miRNA）和长非编码RNA（lncRNA）。新的证据表明 miRNA 和 lncRNA 在许多癌症的形成和进展中发挥着关键作用。在这篇综述中，我们重点关注 miRNA 和 lncRNA 在胃癌中的调控。 miRNA和lncRNA似乎参与胃肿瘤的生长、侵袭和转移，并通过多种机制参与胃肿瘤微环境的建立。此外，我们还讨论了建立 miRNA 和 lncRNA 作为胃癌潜在生物标志物和治疗靶点的可能性。总之，我们总结了 ncRNA 在胃癌发展中的新作用及其可能的临床意义。
Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs (ncRNAs) with cancer has been widely studied during the past decade. In general, ncRNAs have been classified as small ncRNAs, including microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). Emerging evidence shows that miRNAs and lncRNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of miRNAs and lncRNAs in gastric cancer. miRNAs and lncRNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing miRNAs and lncRNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of ncRNAs in gastric cancer development and their possible clinical significance.