Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice
Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice
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DOI：
10.1111/j.1365-2826.2007.01581.x
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发表时间：
2007-09-01
影响因子：
3.2
通讯作者：
Dluzen, D. E.
中科院分区：
文献类型：
--
作者：
Ji, J.;McDermott, J. L.;Dluzen, D. E.
利血平抑制囊泡单胺转运蛋白-2（VMAT-2）的功能，从而损害神经末梢内囊泡多巴胺（DA）的储存。本报告比较了利血平处理对雄性和雌性小鼠纹状体多巴胺能系统的影响，以评估VMAT-2/DA储存功能的潜在性别差异。用利血平治疗后，雄性小鼠纹状体DA浓度和K+诱发的DA输出量显着高于雌性小鼠。相比之下，在利血平处理的小鼠中，甲基苯丙胺诱发的DA输出没有观察到统计学显著的性别差异。这些结果表明，在纹状体多巴胺能反应利血平的明显性别差异，并表明，女性拥有更积极的VMAT-2/DA存储能力，所示的更大程度的赤字时观察到的VMAT-2/DA存储功能被利血平抑制。这些发现对于了解黑质纹状体多巴胺能系统神经毒性和神经变性性别差异的一些基础具有重要意义。
Reserpine inhibits vesicular monoamine transporter-2 (VMAT-2) function and thereby impairs vesicular dopamine (DA) storage within nerve terminals. The present report compared the effects of reserpine treatment upon the striatal dopaminergic system in male and female mice as a means to assess potential sex differences in VMAT-2/DA storage function. After treatment with reserpine, male mice showed significantly greater striatal DA concentrations and K+-evoked DA output from the striatum compared to females. By contrast, no statistically significant sex differences were observed in methamphetamine-evoked DA output in reserpine-treated mice. These results demonstrate a clear sex difference in the striatal dopaminergic responses to reserpine and suggest that females possess a more active VMAT-2/DA storage capacity, as indicated by the greater degree of deficits observed when VMAT-2/DA storage function is inhibited by reserpine. Such findings have important implications for understanding some of the bases for sex differences in neurotoxicity and neurodegeneration of the nigrostriatal dopaminergic system.