Colon and anal sphincter contractions evoked by microstimulation of the sacral spinal cord in cats.
Colon and anal sphincter contractions evoked by microstimulation of the sacral spinal cord in cats.
复制标题
猫骶脊髓的微刺激引起结肠和肛门括约肌收缩。
DOI：
10.1016/s0006-8993(00)03095-x
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发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
Roppolo,JR
中科院分区：
文献类型：
--
作者：
Tai,C;Booth,AM;deGroat,WC;Roppolo,JR
在α-氯蔗糖麻醉的猫上，通过测量脊髓腔内压力的变化，研究了微刺激S2脊髓引起的结肠和肛门括约肌的收缩。刺激骶前根（S1-S3）显示，S2传出流出通常产生最大的结肠反应。刺激S2腹根或脊髓均表明15 Hz刺激是诱发结肠收缩的最佳频率。结肠和肛门括约肌收缩也受到刺激强度和脉宽的影响。S2脊髓中微刺激引起远侧/近侧结肠压力反应大于肛门括约肌反应的位置包括骶骨副交感神经核（SPN）区域、延伸至背侧连合的SPN内侧区域以及腹角深处的区域。肛门括约肌松弛引起的微刺激在更有限的位置在S2脊髓，这似乎与那些引起肛门括约肌收缩重叠。这些结果提示了一种可能的方法，通过用多个微电极微刺激S2脊髓来诱发结肠收缩和排便。
The colon and anal sphincter contractions induced by microstimulation of the S2 spinal cord were investigated by measuring the intraluminal pressure change via saline filled balloons in α-chlorolose anesthetized cats. Stimulation of sacral ventral roots (S1–S3) revealed that the S2 efferent outflow usually produces the largest colon response. Stimulation of the S2 ventral root or the spinal cord both indicated that 15 Hz stimulation was the optimal frequency for evoking colon contractions. Colon and anal sphincter contractions were also influenced by stimulation intensity and pulsewidth. Locations in S2 spinal cord, where microstimulation evoked a distal/proximal colon pressure response that was greater than the anal sphincter response, included the area of sacral parasympathetic nucleus (SPN), the area medial to the SPN extending to the dorsal commissure, and areas deep in the ventral horn. Anal sphincter relaxation was evoked by microstimulation in more restricted locations in S2 spinal cord, which appeared to overlap with those evoking anal sphincter contractions. These results suggest a possible method to evoke colon contraction and defecation by microstimulation of the S2 spinal cord with multiple microelectrodes.