Rotavirus disease - Impact of coinfections
Rotavirus disease - Impact of coinfections
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DOI：
10.1097/inf.0b013e31815eedfa
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Desselberger, Ulrich
中科院分区：
文献类型：
--
作者：
Grimprel, Emmanuel;Rodrigo, Carlos;Desselberger, Ulrich
背景：许多轮状病毒感染是与其他微生物（包括病毒、细菌和原生动物）混合感染。体外、动物和临床研究为轮状病毒感染和共感染病原体之间的增强作用提供了证据。这种相互作用的机制没有得到很好的研究或understanding.Methods：进行文献检索，以确定轮状病毒coinfections.Results：轮状病毒和肠道致病菌，特别是大肠杆菌感染之间的增强的证据。大肠杆菌很强。大量的临床研究表明，感染轮状病毒和细菌性肠道病原体的儿童会出现更严重的腹泻和/或脱水，腹泻的持续时间往往比单纯感染轮状病毒的儿童更长。在一般情况下，但不限于，合并感染的结果在一个较差的pregnancy.Conclusions：在发展中国家，轮状病毒疫苗接种可能会改善与细菌肠道病原体轮状病毒合并感染的不良预后。然而，需要进一步的研究来确定轮状病毒疫苗接种在合并感染中的确切作用。
Background: Many rotavirus infections occur as mixed infections with other microorganisms, including viruses, bacteria, and protozoa. In vitro, animal and clinical studies provide evidence for potentiation between rotavirus infection and coinfecting pathogens. The mechanisms of such interactions are not well studied or understood.Methods: A literature search was performed to identify publications on rotavirus coinfections.Results: The evidence for potentiation between infections with rotavirus and bacterial enteropathogens-particularly E. coli-is strong. A number of large clinical investigations has shown that children infected with rotavirus and a bacterial enteropathogen suffer from more severe diarrhea and/or dehydration, with diarrhea often lasting longer than in children infected with rotavirus alone. In general, but not exclusively, coinfections result in a poorer prognosis.Conclusions: In developing countries, rotavirus vaccination could possibly improve the poor prognosis associated with bacterial enteropathogen-rotavirus coinfections. However, further studies are needed to define the exact role of rotavirus vaccination in the context of coinfections.