Endurance running during late murine adolescence results in a stronger anterior cruciate ligament and flatter posterior tibial slopes compared to controls.
Endurance running during late murine adolescence results in a stronger anterior cruciate ligament and flatter posterior tibial slopes compared to controls.
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DOI：
10.1186/s40634-021-00439-7
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发表时间：
2022-01-03
影响因子：
1.8
通讯作者：
Schlecht SH
中科院分区：
文献类型：
--
作者：
Ochocki DN;Loflin BE;Ahn T;Colglazier KA;Young AR;Snider AA;Bueckers EP;Wojtys EM;Schlecht SH
前交叉韧带（ACL）损伤率在参与娱乐和竞技体育的年轻人中继续上升，需要更好地了解膝关节在肌肉骨骼生长过程中的结构和机械反应。关于ACL损伤的解剖学风险因素（例如，ACL尺寸小、髁间窝窄、胫骨后斜坡陡）在整个生长过程中随着身体活动的增加而发展并做出反应。我们假设小鼠的ACL复合体参与中度到剧烈的体力活动（即，耐力跑）在整个青春期后期和青年期会积极地在功能上适应重复的负荷扰动。雌性C57 BL 6/J小鼠（8周龄）可自由接近具有增加阻力的标准笼轮（n = 18）或正常笼活动（n = 18），持续4周。记录每日长跑、每周体重和食物重量以及研究前和研究后的身体组成测量。在研究完成时，量化了跑步者和非跑步者的肌肉重量、三维膝关节形态、ACL横截面积和ACL机械性能。使用双向方差分析和Tukey多重比较检验评估跑步者和非跑步者之间的统计学比较，体重作为协变量。与非跑步者相比，跑步者的股四头肌（p = 0.02）和腓肠肌（p = 0.05）肌肉更大，但腘绳肌（p = 0.05）肌肉更小。虽然ACL大小没有显著差异（p = 0.24），但跑步者的ACL大小要高出13%（p = 0.03）。此外，胫骨后内侧和外侧倾斜度均比非跑步者平坦1.2 ~ 2.2度（p < 0.01）。在近交系小鼠中，膝关节对中度至剧烈运动的积极功能适应性为ACL损伤的一些解剖学风险因素可能通过习惯性体力活动减少提供了希望。然而，需要确认人类对负荷的类似反应。
Anterior cruciate ligament (ACL) injury rates continue to rise among youth involved in recreational and competitive athletics, requiring a better understanding of how the knee structurally and mechanically responds to activity during musculoskeletal growth. Little is understood about how anatomical risk factors for ACL injury (e.g., small ACL size, narrow intercondylar notch, and steep posterior tibial slope) develop and respond to increased physical activity throughout growth. We hypothesized that the ACL-complex of mice engaged in moderate to strenuous physical activity (i.e., endurance running) throughout late adolescence and young adulthood would positively functionally adapt to repetitive load perturbations. Female C57BL6/J mice (8 weeks of age) were either provided free access to a standard cage wheel with added resistance (n = 18) or normal cage activity (n = 18), for a duration of 4 weeks. Daily distance ran, weekly body and food weights, and pre- and post-study body composition measures were recorded. At study completion, muscle weights, three-dimensional knee morphology, ACL cross-sectional area, and ACL mechanical properties of runners and nonrunners were quantified. Statistical comparisons between runners and nonrunners were assessed using a two-way analysis of variance and a Tukey multiple comparisons test, with body weight included as a covariate. Runners had larger quadriceps (p = 0.02) and gastrocnemius (p = 0.05) muscles, but smaller hamstring (p = 0.05) muscles, compared to nonrunners. Though there was no significant difference in ACL size (p = 0.24), it was 13% stronger in runners (p = 0.03). Additionally, both the posterior medial and lateral tibial slopes were 1.2 to 2.2 degrees flatter than those of nonrunners (p < 0.01). Positive functional adaptations of the knee joint to moderate to strenuous exercise in inbred mice offers hope that that some anatomical risk factors for ACL injury may be reduced through habitual physical activity. However, confirmation that a similar response to loading occurs in humans is needed.
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影响因子：
3.8
作者：
Schlecht SH;Ramcharan MA;Yang Y;Smith LM;Bigelow EM;Nolan BT;Moss DE;Devlin MJ;Jepsen KJ
通讯作者：
Jepsen KJ
影响因子：
5.3
作者：
Hashemi, Javad;Chandrashekar, Naveen;Dabezies, Eugene
通讯作者：
Dabezies, Eugene
影响因子：
4.8
作者：
CABAUD, HE;CHATTY, A;FELTMAN, RJ
通讯作者：
FELTMAN, RJ
DOI：
10.1177/03635465211012354
发表时间：
2021-07
期刊：
The American journal of sports medicine
影响因子：
--
作者：
Beaulieu ML;DeClercq MG;Rietberg NT;Li SH;Harker EC;Weber AE;Ashton-Miller JA;Wojtys EM
通讯作者：
Wojtys EM
DOI：
10.1186/s12966-020-01037-z
发表时间：
2020-11-26
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Chaput JP;Willumsen J;Bull F;Chou R;Ekelund U;Firth J;Jago R;Ortega FB;Katzmarzyk PT
通讯作者：
Katzmarzyk PT