Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002
Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002
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DOI：
10.1016/j.jaad.2006.09.006
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发表时间：
2007-06-01
影响因子：
13.8
通讯作者：
Weinstock, Martin A.
中科院分区：
文献类型：
--
作者：
Criscione, Vincent D.;Weinstock, Martin A.
背景资料：隆突性皮肤纤维肉瘤（DFSP）的流行病学尚未详细研究。目的：我们试图描述的DFSP的发病率和生存在UnitedStates.Methods：数据来自9个人口为基础的癌症登记处的监测，流行病学，和最终结果计划1973年至2002年。在研究期间，发病率增加了43%（每年每百万人3.1-4.4），但这种增加仅限于白人。黑人的年发病率（6.5/100万）几乎是白人的两倍（3.9/100万; P <0.005，95%置信区间差异2.02-3.22）。女性的发病率高于男性（每年每百万人4.4 vs 4.2; P = 0.052，差异的95%置信区间为-0.002至0.60），老年人除外。相对5年生存率为99.2%（95%置信区间98.3-100%）。局限性：监测，流行病学和最终结果程序缺乏独立的诊断和病例details.Conclusions验证：种族差异的发病率DFSP是显着的，原因是未知的。以前的文献表明，男性更经常受到影响，这在我们的数据中是不正确的。肿瘤很少导致死亡。使用基于人群的数据进行流行病学调查对于更好地了解这种疾病非常重要。
Background: The epidemiology of dermatofibrosarcoma protuberans (DFSP) has not been studied in detail.Objective: We sought to describe patterns of DFSP incidence and survival in the United States.Methods: Data were obtained from 9 population-based cancer registries of the Surveillance, Epidemiology, and End Results Program for 1973 to 2002.Results: DFSP overall annual incidence was 4.2 per million. Incidence increased by 43% (3.1-4.4 per million per year) during the study period, but this increase was restricted to whites. Annual incidence among blacks (6.5 per million) was almost double the incidence among whites (3.9 per million; P < .005 95% confidence interval of difference 2.02-3.22). Women had higher rates of incidence than men (4.4 vs 4.2 per million per year; P = .052, 95% confidence interval of difference -0.002 to 0.60), except among the elderly. Relative 5-year Survival was 99.2% (95% confidence interval 98.3-100%).Limitations: The Surveillance, Epidemiology, and End Results Program lacks independent verification of diagnoses and case detail.Conclusions: The racial differences in the incidence of DFSP are significant, and the cause is unknown. Previous literature had suggested that men were more frequently affected, which was not true in our data. The tumor rarely results in death. Epidemiologic investigation using population-based data is important to better understand this disorder.