Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
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DOI：
10.1046/j.1365-2362.2003.01152.x
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发表时间：
2003-05-01
影响因子：
5.5
通讯作者：
Sirigu, P
中科院分区：
文献类型：
--
作者：
Ribatti, D;Ennas, MG;Sirigu, P
背景：血管生成在黑色素瘤中的重要性一直存在争议，而且不是同质性的。肥大细胞密度(MCD)与正常和病理血管生成的程度高度相关，如在慢性炎症性疾病和肿瘤中。方法我们评估了25例晚期黑色素瘤患者手术后和4~5年随访的肿瘤微血管密度(MVD)和MCD的预后意义：48%的患者存活且无转移(预后良好亚组)；16%的患者出现区域淋巴结转移(中度预后亚组)；36%的患者死亡(预后不良亚组)。结果免疫组织化学染色显示恶性黑色素瘤组织中微血管和肥大细胞的数量明显高于预后较差和预后较好的病变。结论MCD与肿瘤进展过程中血管生成密切相关，首次证实了MCD在黑色素瘤中的预后意义。
Background The importance of angiogenesis in melanoma has been controversial and is not homogeneous. Mast cell density (MCD) is highly correlated with the extent of both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumours.Methods We evaluated the prognostic significance of tumour microvascular density (MVD) and MCD in 25 advanced melanoma patients after resection and a 4-5-year follow up: 48% of the patients were alive and free of metastases (good prognostic subgroup); 16% had developed regional nodal metastases (intermediate prognostic subgroup); and 36% had died (poor prognostic subgroup). Tissues samples were investigated immunohistochemically to count microvessels and mast cells with an antifactor VIII and an antitryptase antibody, respectively.Results Immunohistological staining showed a higher number of microvessels and mast cells in melanoma lesions of poor prognosis as compared with intermediate prognosis and with good prognosis, respectively.Conclusions These data agree with those showing a close relationship between MCD and angiogenesis during tumour progression and demonstrate, for the first time, a prognostic significance of MCD in human melanoma.