Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus Roux-en-Y gastric bypass: A pilot study
Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus Roux-en-Y gastric bypass: A pilot study
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DOI：
10.1016/j.soard.2013.07.014
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发表时间：
2014-03-01
影响因子：
3.1
通讯作者：
Lambrinoudaki, Irene
中科院分区：
文献类型：
--
作者：
Alexandrou, Andreas;Armeni, Eleni;Lambrinoudaki, Irene
背景：营养缺乏在肥胖患者中非常普遍。减肥手术与对重要维生素和微量营养素的体内平衡的不良影响有关，主要是在胃旁路手术后。本研究的目的是比较Roux-en-Y胃旁路术（RYGB）和袖状胃切除术（SG）之间的长期术后营养不良的程度。方法：本横断面，试点研究包括95例接受RYGB或SG手术的患者，平均随访4年。根据手术类型比较人口统计学、人体测量学和生化参数。结果：两种类型的手术均与显著的营养缺乏相关。维生素B12缺乏症在RYGB患者中显著高于SG患者（42.1%对5%，P = 0.003）。手术类型与贫血、铁或叶酸缺乏无关（SG与RYGB：贫血，54.2%与64.3%，P = .418;叶酸缺乏，20%与18.4%，P = .884;铁缺乏，30%与36.4%，P = .635）。在RYGB或SG后平均4年的随访期间，患者被确定患有几种微量营养素缺乏症，包括维生素D，叶酸和维生素B12。与RYGB相比，SG可能对维生素B12的代谢具有更有利的影响，与较少的吸收不良相关。坚持补充铁和维生素的摄入是所有减肥手术的主要意义。(C)2014年美国代谢和减肥外科学会。All rights reserved.
Background: Nutritional deficiencies are highly prevalent in obese patients. Bariatric surgery has been associated with adverse effects on homeostasis of significant vitamins and micronutrients, mainly after gastric bypass. The aim of the present study was to compare the extent of long-term postsurgical nutritional deficiencies between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).Methods: This cross-sectional, pilot study included 95 patients who underwent RYGB or SG surgery with a mean follow-up of 4 years. Demographic, anthropometric, and biochemical parameters were compared according to the type of surgery.Results: Both types of surgery were associated with significant nutritional deficiencies. Vitamin B12 deficiency was significantly higher in patients with RYGB compared with SG (42.1% versus 5%, P = .003). The type of surgery was associated neither with anemia nor with iron or folate deficiency (SG versus RYGB: anemia, 54.2% versus 64.3%, P = .418; folate deficiency, 20% versus 18.4%, P = .884; iron deficiency, 30% versus 36.4%, P = .635).Conclusion: During a mean follow up period of 4 years postRYGB or SG, patients were identified with several micronutrient deficiencies, including vitamin D, folate, and vitamin B12. SG may have a more favorable effect on the metabolism of vitamin B12 compared with RYGB, being associated with less malabsorption. Adherence to supplemental iron and vitamin intake is of primary significance in all cases of bariatric surgery. (C) 2014 American Society for Metabolic and Bariatric Surgery. All rights reserved.