Foxp3 expressed by tongue squamous cell carcinoma cells correlates with clinicopathologic features and overall survival in tongue squamous cell carcinoma patients
Foxp3 expressed by tongue squamous cell carcinoma cells correlates with clinicopathologic features and overall survival in tongue squamous cell carcinoma patients
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舌鳞状细胞癌细胞表达的Foxp3与舌鳞状细胞癌患者的临床病理特征和总生存期相关
DOI：
10.1016/j.oraloncology.2011.04.017
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发表时间：
2011-07-01
期刊：
影响因子：
4.8
通讯作者：
Liao, Gui-qing
中科院分区：
文献类型：
--
作者：
Liang, Yu-jie;Liu, Hai-chao;Liao, Gui-qing
叉头转录因子Foxp3已被鉴定为CD4（+）CD25（+）Foxp3（+）调节性T细胞（TCLs）功能的关键参与者和TCLs的决定性标志物。最近有报道称Foxp3可以由肿瘤细胞自身表达。本研究旨在探讨Foxp3在舌鳞状细胞癌（TSCC）细胞中的表达及其临床意义。本研究采用免疫组化染色、实时荧光定量PCR和Western blotting方法检测Foxp3在TSCC组织标本和3种TSCC细胞系中的表达，并分析其临床意义。81例TSCC石蜡包埋标本中48例（59.3%）免疫组化染色阳性。其表达与肿瘤分化程度（P = 0.040）、T分期（P = 0.000）显著相关，与患者生存期呈负相关（P = 0.021）。多因素分析（考克斯回归）显示Foxp3表达是TSCC的独立预后指标（P = 0.032）。(C)2011爱思唯尔有限公司保留所有权利。
The forkhead transcription factor, Foxp3, has been identified as a key player in CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) function and a definitive marker of Tregs. Recently, it was reported that Foxp3 could be expressed by tumor cells themselves. The present study was to investigate the expression of Foxp3 in tongue squamous cells carcinoma (TSCC) cells and its clinical significance. In this study, the expression of Foxp3 by TSCC cells was demonstrated in TSCC tissue samples and three TSCC cell lines using immunohistochemical staining, realtime-PCR and Western blotting, and its clinical significance were statistically analyzed. The immunohistochemical assay in TSCC paraffin-embedded samples showed positive staining in 48 of 81 (59.3%) cases. The expression was significantly associated with pathologic differentiation (P = 0.040) and T stage (P = 0.000), and furthermore, inversely associate with patient survival (P = 0.021). Multivariate analysis (Cox regression) suggested that Foxp3 expression in TSCC cells was an independent prognostic indicator for TSCC (P = 0.032). (C) 2011 Elsevier Ltd. All rights reserved.