Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically
Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically
复制标题
DOI：
10.1159/000351145
复制
发表时间：
2013-01-01
期刊：
影响因子：
3.5
通讯作者：
Ranieri, Girolamo
中科院分区：
文献类型：
--
作者：
Ammendola, Michele;Sacco, Rosario;Ranieri, Girolamo
背景：血管生成已被发现是几种类型恶性肿瘤的可靠预后指标。胰蛋白酶是储存在肥大细胞（MC）颗粒中的丝氨酸蛋白酶，在肿瘤血管生成中起作用。c-Kit受体激活后，MCs可释放胰蛋白酶。方法：本研究采用免疫组织化学、图像分析方法和临床方面的方法，对41例T3-4N2a-bM0期（美国癌症联合委员会，AJCC，结直肠癌，第7版）和T3N2-3M0期（美国癌症联合委员会，胃癌，第7版）的胃肠道肿瘤患者进行分析，评估肿瘤组织中胰蛋白酶（MCPT）阳性MCs与转移淋巴结数量的可能相关性。结果：数据显示肿瘤组织中MCPT与转移淋巴结数量呈正相关；这些数据的有效性需要在更大的患者队列中得到证实。结论：这是首次将肿瘤组织中MCPT作为手术治疗类型及其根治性的有效指征的潜在工具，可作为根治性手术治疗前患者预后的参考。我们的试点数据需要在更大的患者群体中得到证实。巴塞尔S. Karger股份有限公司版权所有
Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort. Copyright (C) 2013 S. Karger AG, Basel