Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
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DOI：
10.1016/j.bmcl.2006.07.018
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发表时间：
2006-09-15
影响因子：
2.7
通讯作者：
Ahn, Jong Seog
中科院分区：
文献类型：
--
作者：
Na, MinKyun;Jang, JunPil;Ahn, Jong Seog
脂肪酸合成酶(FAS)正在成为治疗癌症和肥胖症的潜在靶点。采用体外Fas抑制法对鳞毛蕨根状茎的甲醇提取物进行了分离，得到了一系列的酰基间苯三酚作为活性成分。菌株1-10对Fas有抑制作用，IC50值在23.1+/-1.4~71.7+/-3.9mM之间。(C)2006爱思唯尔有限公司。保留所有权利。
Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1-10 inhibited FAS with IC50 values ranging from 23.1 +/- 1.4 to 71.7 +/- 3.9 mu M. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors. (c) 2006 Elsevier Ltd. All rights reserved.