The right VLPFC and downregulation of social pain: A TMS study
The right VLPFC and downregulation of social pain: A TMS study
复制标题
DOI：
10.1002/hbm.24881
复制
发表时间：
2019-12-02
影响因子：
4.8
通讯作者：
Zhang, Dandan
中科院分区：
文献类型：
--
作者：
He, Zhenhong;Zhao, Jun;Zhang, Dandan
先前的研究表明，右腹外侧前额叶皮层（RVLPFC）在下调身体和社会疼痛方面发挥着至关重要的作用。然而，目前尚不清楚 RVLPFC 是否对身体疼痛或社交疼痛更具有特异性。本研究使用重复经颅磁刺激 (rTMS) 比较了 RVLPFC 在身体和社交疼痛条件下情绪调节中的作用。共有 60 名健康参与者在 RVLPFC 上接受了主动 (n = 30) 或假 (n = 30) rTMS。在每次 TMS 会议之后，参与者执行非重新评估任务，然后执行重新评估任务，以下调图片引起的想象中的身体或社会疼痛。在情绪调节任务期间记录自我报告的负面情绪评级和脑电图数据。然后，参与者被要求在任务完成 30 分钟后对这些图片的效价和唤醒度进行评分。研究发现，rTMS 激活的 RVLPFC 导致重新评估期间主观负面情绪和晚期正电位幅度的减少；然而，这些影响只出现在社会痛苦的情况下。任务完成 30 分钟后，与身体上的痛苦图片相比，参与者还报告了社交上的积极效价更高。行为学和电生理学证据均支持 RVLPFC 在调节社交疼痛方面的功能特异性。 rTMS 显着的延迟效应使得考虑 rTMS-VLPFC 在缓解社会疼痛的临床实践中的潜在应用成为可能。
Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regulation in physical- and social-pain conditions using repetitive transcranial magnetic stimulation (rTMS). A total of 60 healthy participants underwent active (n = 30) or sham (n = 30) rTMS over the RVLPFC. Following each TMS session, participants performed a non-reappraisal and then a reappraisal task to downregulate imagined physical or social pain evoked by pictures. Self-reported negative emotional ratings and electroencephalogram data were recorded during the emotion regulation task. Participants were then required to rate the valence and arousal of those pictures 30 min after the task. It is found that rTMS-activated RVLPFC led to reductions in subjective negative feelings and amplitudes of the late positive potential during reappraisal; however, these effects were found exclusively in the social-pain condition. Participants also reported higher positive valence for socially, compared to physically, painful pictures after 30 min of the task. Behavioral and electrophysiological evidence both supported the functional specificity of RVLPFC in regulation of social pain. The prominent delayed effect of rTMS makes it possible to consider the potential application of rTMS-VLPFC in clinical practice for social pain relief.