Mitochondrial calcium uptake regulates cold preservation-induced Bax translocation and early reperfusion apoptosis
Mitochondrial calcium uptake regulates cold preservation-induced Bax translocation and early reperfusion apoptosis
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DOI:
10.1111/j.1600-6143.2004.00357.x
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发表时间:
2004-03-01
影响因子:
8.8
通讯作者:
Chari, RS
中科院分区:
文献类型:
--
作者:
Anderson, CD;Belous, A;Chari, RS
Mitochondrial calcium (mCa + 2) overload occurs during cold preservation and is an integral part of mitochondrial-dependent apoptotic pathways. We investigated the role of mCa + 2 overload in cell death following hypothermic storage using HepG2 cells stored in normoxic-hypothermic (4 degreesC) or hypoxic (