Inhalation Anesthesia Is Preferable for Recording Rat Cardiac Function Using an Electrocardiogram
Inhalation Anesthesia Is Preferable for Recording Rat Cardiac Function Using an Electrocardiogram
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DOI：
10.1248/bpb.b14-00012
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发表时间：
2014-05-01
影响因子：
2
通讯作者：
Ohba, Takayoshi
中科院分区：
文献类型：
--
作者：
Murakami, Manabu;Niwa, Hidetoshi;Ohba, Takayoshi
采用心电图（ECG）和血氧饱和度（SPO 2）水平测定，比较了吸入麻醉（2%异氟烷、七氟烷或恩氟烷）和戊巴比妥（65 mg/kg）腹腔内麻醉对大鼠的影响。吸入麻醉后，心率（BR）和SPO 2可接受，而戊巴比妥麻醉则显著降低HR和SPO 2。这表明在评价心血管因素时，吸入麻醉比戊巴比妥麻醉更可取。此外，戊巴比妥显著增加心率变异性（HRV），表明戊巴比妥对自主神经系统的调节作用，并导致压力反射系统的反应降低。普萘洛尔或阿托品对戊巴比妥麻醉后ECG记录的影响有限。综上所述，这些数据表明，吸入麻醉适用于在大鼠中进行血流动力学分析。
The effects of inhalation anesthesia (2% isoflurane, sevoflurane, or enflurane) and intraperitoneal anesthesia with pentobarbital (65 mg/kg) were compared in rats using an electrocardiogram (ECG) and determination of blood oxygen saturation (SPO2) levels. Following inhalation anesthesia, heart rate (BR) and SPO2 were acceptable while pentobarbital anesthesia decreased HR and SPO2, significantly. This indicates that inhalation anesthesia is more preferable than pentobarbital anesthesia when evaluating cardiovascular factors. Additionally, pentobarbital significantly increased HR variability (HRV), suggesting a regulatory effect of pentobarbital on the autonomic nervous system, and resulted in a decreased response of the baro-reflex system. Propranolol or atropine had limited effects on ECG recording following pentobarbital anesthesia. Taken together, these data suggest that inhalation anesthesia is suitable for conducting hemodynamic analyses in the rat.