The casein kinase I family: roles in morphogenesis.
The casein kinase I family: roles in morphogenesis.
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DOI：
10.1006/dbio.2001.0307
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发表时间：
2001-07
影响因子：
2.7
通讯作者：
R. McKay;J. M. Peters;J. Graff
中科院分区：
文献类型：
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作者：
R. McKay;J. M. Peters;J. Graff
WNT信号在发育和肿瘤发生中起着重要的作用，至少通过两条途径进行传递：典型的β-连环蛋白依赖性和非β-连环蛋白依赖的级联反应。酪蛋白激酶I(CKI)在无脊椎动物和脊椎动物中都是传递典型的Wnt信号所必需的。然而，它在β-连环蛋白非依赖性途径中的作用尚不清楚。在脊椎动物胚胎发育过程中，β-连环素级联被认为控制细胞的运动，并被认为类似于果蝇平面细胞的极性途径，后者通过JNK级联传递信号。在这里，我们报告了阻断CKI功能抑制胚胎形态发生并激活细胞系中的JNK。这些研究表明，CKI也可能在β-连环素非依赖性途径中发挥作用，并表明CKI在脊椎动物早期发育的收敛延伸过程中发挥了作用。
Wnt signals play important roles in development and oncogenesis and are transduced through at least two pathways: a canonical beta-catenin-dependent and a beta-catenin-independent cascade. Casein kinase I (CKI) is required in both invertebrates and vertebrates to transduce canonical Wnt signals. However, its role in the beta-catenin-independent pathway was unknown. During vertebrate embryogenesis, the beta-catenin-independent cascade is thought to control cell movements and has been postulated to be analogous to the Drosophila planar cell polarity pathway, which signals through the JNK cascade. Here, we report that blocking CKI function inhibits embryonic morphogenesis and activates JNK in cell lines. These studies suggest that CKI might also act in the beta-catenin-independent pathway and indicate a role for CKI during convergence extension in early vertebrate development.