A 3D printable tissue adhesive.
A 3D printable tissue adhesive.
复制标题
一种可 3D 打印的组织粘合剂。
DOI：
10.1038/s41467-024-45147-9
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发表时间：
2024
影响因子：
16.6
通讯作者：
Zhao,Xuanhe
中科院分区：
文献类型：
--
作者：
Wu,SarahJ;Wu,Jingjing;Kaser,SamuelJ;Roh,Heejung;Shiferaw,RuthD;Yuk,Hyunwoo;Zhao,Xuanhe
组织粘合剂是缝合线和U形钉的有前景的替代品，用于连接组织、密封缺损和固定装置。然而，现有的粘合剂大多采用胶水或水凝胶的形式，其通用性有限。我们报告了一种直接墨水写入 3D 打印组织粘合剂，可用于制造具有可编程架构的生物粘合剂贴片和设备，从而释放特定应用设计的新潜力。该粘合剂具有舒适性和可拉伸性，可在数秒内与湿纸巾实现牢固的粘合，并具有良好的生物相容性。体内大鼠气管和结肠缺损模型证明了印刷贴片的不透流体的组织密封能力，可在 4 周内保持粘附力。此外，加入排斥血液的疏水基质使打印的贴片能够密封活跃出血的组织。除了伤口闭合之外，3D 打印粘合剂在各种组织接口设备中具有广泛的适用性，这通过代表性的概念验证设计得到了强调。总之，该平台为开发先进的组织粘合技术提供了一个有前景的策略。
Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies.