Functional Correlates of the Anterolateral Processing Hierarchy in Human Auditory Cortex
Functional Correlates of the Anterolateral Processing Hierarchy in Human Auditory Cortex
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DOI：
10.1523/jneurosci.1448-11.2011
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发表时间：
2011-06-22
影响因子：
5.3
通讯作者：
Rauschecker, Josef P.
中科院分区：
文献类型：
--
作者：
Chevillet, Mark;Riesenhuber, Maximilian;Rauschecker, Josef P.
汇聚的证据支持这样的假设：前外侧处理通路介导听觉皮层的声音识别，类似于腹侧皮层通路在视觉物体识别中的作用。对非人类灵长类动物的研究将前外侧听觉通路描述为一个处理层次结构，由三个解剖学和生理学上不同的初始阶段组成：核心、带和帕拉带。在人类中，这些区域的潜在同源物已在解剖学上得到鉴定，但它们之间可靠且完整的功能区别尚未确定。由于这些区域的解剖位置因受试者而异，因此对猴子和人类之间潜在同源性的研究需要在单个受试者中定义这些区域。使用功能性 MRI，我们呈现了三类声音（音调、带通噪声爆发和同种发声），相当于之前猴子研究中使用的声音。在每个受试者中，很容易识别出与猕猴核心、带和帕拉带功能相似的三个区域。此外，这些区域的相对大小和位置与人体解剖学研究中报告的一致。我们的结果表明，人类前外侧处理通路的功能组织与非人类灵长类动物的功能组织基本一致。由于我们的扫描会话每个对象仅持续 15 分钟，因此它们可以与其他扫描一起运行。这将使未来的研究能够以以前只能在视觉皮层中实现的细节水平来表征人类听觉皮层中的功能模块。此外，在人类和猴子中使用相同方案的方法将有助于建立它们之间潜在的同源性。
Converging evidence supports the hypothesis that an anterolateral processing pathway mediates sound identification in auditory cortex, analogous to the role of the ventral cortical pathway in visual object recognition. Studies in nonhuman primates have characterized the anterolateral auditory pathway as a processing hierarchy, composed of three anatomically and physiologically distinct initial stages: core, belt, and parabelt. In humans, potential homologs of these regions have been identified anatomically, but reliable and complete functional distinctions between them have yet to be established. Because the anatomical locations of these fields vary across subjects, investigations of potential homologs between monkeys and humans require these fields to be defined in single subjects. Using functional MRI, we presented three classes of sounds (tones, band-passed noise bursts, and conspecific vocalizations), equivalent to those used in previous monkey studies. In each individual subject, three regions showing functional similarities to macaque core, belt, and parabelt were readily identified. Furthermore, the relative sizes and locations of these regions were consistent with those reported in human anatomical studies. Our results demonstrate that the functional organization of the anterolateral processing pathway in humans is largely consistent with that of nonhuman primates. Because our scanning sessions last only 15 min/subject, they can be run in conjunction with other scans. This will enable future studies to characterize functional modules in human auditory cortex at a level of detail previously possible only in visual cortex. Furthermore, the approach of using identical schemes in both humans and monkeys will aid with establishing potential homologies between them.