Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
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DOI：
10.1128/jvi.78.11.6073-6076.2004
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发表时间：
2004-06-01
影响因子：
5.4
通讯作者：
Peterlin, BM
中科院分区：
文献类型：
--
作者：
Zheng, YH;Irwin, D;Peterlin, BM
最近，APOBEC3G已被确定为阻止逆转录病毒复制的宿主因子。它在靶细胞的逆转录过程中引入了新合成的负链病毒cDNAG到A的高突变。在这里，我们确定人类APOBEC3F蛋白是另一个阻止人类免疫缺陷病毒1型(HIV-1)复制的宿主因子。与APOBEC3G相似，APOBEC3F也诱导HIV基因组DNA G到A的过度突变，病毒Vif蛋白抵消了其活性。因此，APOBEC家族成员可能进化为机体对逆转录病毒、反转录转座子和其他可移动遗传元件的一般防御机制。
Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step of reverse transcription in target cells. Here, we identified the human APOBEC3F protein as another host factor that blocks human immunodeficiency virus type 1 (HIV-1) replication. Similar to APOBEC3G, APOBEC3F also induced G to A hypermutations in HIV genomic DNA, and the viral Vif protein counteracted its activity. Thus, APOBEC family members might have evolved as a general defense mechanism of the body against retroviruses, retrotransposons, and other mobile genetic elements.