Social enrichment improves social recognition memory in male rats
Social enrichment improves social recognition memory in male rats
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DOI：
10.1007/s10071-018-1171-5
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发表时间：
2018-05-01
期刊：
影响因子：
2.7
通讯作者：
Ichitani, Yukio
中科院分区：
文献类型：
--
作者：
Toyoshima, Michimasa;Yamada, Kazuo;Ichitani, Yukio
社会环境被认为对认知功能有很大的影响。在目前的研究中，我们使用“不同对象任务”(DOT)来研究社会充实是否会影响大鼠的记忆能力。在“不同对象任务”中，记忆负荷的水平可以通过改变要记忆的对象的数量来调节。此外，我们将DOT应用于一项使用不熟悉的同种青少年而不是物体的社会歧视任务。动物在断奶后[出生后21天]被安置在三种不同的居住条件中的一种：社会隔离(每笼1只)、标准(每笼3只)或社会丰富(每笼10只)。在PND 60上进行了物体识别和社会识别任务。在样本阶段，大鼠被允许探索一个领域，其中有3、4或5种不同的、不熟悉的刺激(通过网格或物体呈现的同种幼虫)。在延迟5分钟后进行的测试阶段，只有在呈现三个不同同种的条件下，社会分离的大鼠才能区分新的同种和熟悉的同种；社会丰富的大鼠即使在五个不同的同种的条件下也能够识别新的同种。另一方面，在物体识别任务中，在五种不同物体的条件下，社会分离大鼠和社会丰富大鼠都能区分新物体和熟悉物体。这些结果表明，社会财富可以提高社会记忆广度，但不能提高客体记忆广度。
The social environment is thought to have a strong impact on cognitive functions. In the present study, we investigated whether social enrichment could affect rats' memory ability using the "Different Objects Task (DOT)," in which the levels of memory load could be modulated by changing the number of objects to be remembered. In addition, we applied the DOT to a social discrimination task using unfamiliar conspecific juveniles instead of objects. Animals were housed in one of the three different housing conditions after weaning [postnatal day (PND) 21]: social-separated (1 per cage), standard (3 per cage), or social-enriched (10 per cage) conditions. The object and social recognition tasks were conducted on PND 60. In the sample phase, the rats were allowed to explore a field in which 3, 4, or 5 different, unfamiliar stimuli (conspecific juveniles through a mesh or objects) were presented. In the test phase conducted after a 5-min delay, social-separated rats were able to discriminate the novel conspecific from the familiar ones only under the condition in which three different conspecifics were presented; social-enriched rats managed to recognize the novel conspecific even under the condition of five different conspecifics. On the other hand, in the object recognition task, both social-separated and social-enriched rats were able to discriminate the novel object from the familiar ones under the condition of five different objects. These results suggest that social enrichment can enhance social, but not object, memory span.