Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.
Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.
复制标题
色素上皮衍生因子因口服葡萄糖负荷而下降，并且与维生素 D 和 BMI 相关，但与儿童和年轻人的糖尿病状况无关。
DOI：
10.1159/000466692
复制
发表时间：
2017
影响因子：
3.2
通讯作者：
Rother,KristinaI
中科院分区：
文献类型：
--
作者：
Sylvetsky,AllisonC;Issa,NajyT;Chandran,Avinash;Brown,RebeccaJ;Alamri,HussamJ;Aitcheson,Gabriella;Walter,Mary;Rother,KristinaI
背景色素上皮衍生因子(PEDF)与成人肥胖和糖尿病并发症有关，但对年轻人的PEDF知之甚少。我们在年轻的健康志愿者和年龄相近的糖尿病患者(1型和2型)中调查了PEDF与各种代谢生物标志物的关系。方法采集48例健康志愿者(HV)、11例1型糖尿病(T1D)和11例12~25岁2型糖尿病(T2D)患者的空腹血标本。在9名健康受试者中，还在频繁采样的口服葡萄糖耐量试验(OGTT)中连续测量了PEDF。结果PEDF与BMI、收缩压呈正相关，与维生素D呈负相关。经多因素分析，BMI、维生素D是PEDF的独立预测因子。调整前，T2D患者的PEDF值最高(7168.9±4417.4 ng/m L)，T1D患者的PEDF值最低(2967.7±947.1 ng/m L)，但在调整了体重指数和维生素D后，在接受口服葡萄糖负荷的志愿者中，PEDF值下降了约20%。结论PEDF受糖负荷调节，与BMI相关，但与糖尿病无关。与维生素D的负相关性，独立于BMI，提出了PEDF是否在骨基质矿化中起到补偿作用的问题。
Background Pigment epithelium-derived factor (PEDF) is associated with obesity and diabetes complications in adults, yet little is known about PEDF in younger individuals. We investigated the relationship between PEDF and various metabolic biomarkers in young healthy volunteers and similar-aged patients with diabetes (type 1 and type 2). Methods A fasting blood sample was collected in 48 healthy volunteers (HV), 11 patients with type 1 diabetes (T1D) and 11 patients with type 2 diabetes (T2D) 12–25 years of age. In 9 healthy subjects, PEDF was also serially measured during a frequently-sampled oral glucose tolerance test (OGTT). Results PEDF was positively correlated with BMI and systolic blood pressure and negatively correlated with Vitamin D. Upon multivariable analysis, BMI and vitamin D were independent predictors of PEDF. Prior to adjustment, PEDF was highest (7168.9 ± 4417.4 ng/mL) in T2D patients and lowest in individuals with T1D (2967.7 ± 947.1 ng/mL), but did not differ by diagnosis when adjusted for BMI and vitamin D. Among volunteers who underwent an OGTT, PEDF declined by ~20% in response to an oral glucose load. Conclusion PEDF was acutely regulated by a glucose load and correlated with BMI, but was not correlated with diabetes. The negative correlation with vitamin D, independent of BMI, raises the question whether PEDF plays a compensatory role in bone matrix mineralization.