Neuraminidase Inhibitory Polyketides from the Marine-derived Fungus Phoma herbarum
Neuraminidase Inhibitory Polyketides from the Marine-derived Fungus Phoma herbarum
复制标题
来自海洋源性真菌 Phoma herbarum 的神经氨酸酶抑制性聚酮化合物
DOI：
10.1055/s-0031-1280251
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发表时间：
2012-01-01
期刊：
影响因子：
2.7
通讯作者：
Ge, Hui Ming
中科院分区：
文献类型：
--
作者：
Zhang, Gao Fei;Han, Wen Bo;Ge, Hui Ming
从海源真菌Phoma herbarum培养液中分离到两个新的聚酮，arthropsadiol C(1)和massarilactone H(2)，以及6个已知衍生物（3-8）。利用包括二维核磁共振在内的光谱学方法对它们的结构进行了分析。化合物2、4、5和8表现出中等的神经氨酸酶抑制活性，IC50值在4.15 ~ 9.16 μ M之间。
Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.15 to 9.16 mu M.