NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression.
NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression.
复制标题
NSAID 诱导的胃窦溃疡与粘膜基因表达的明显变化有关。
DOI：
10.1111/j.1365-2036.2009.04000.x
复制
发表时间：
2009
影响因子：
7.6
通讯作者：
Aisenberg,J
中科院分区：
文献类型：
--
作者：
Desai,JC;Goo,T;Fukata,M;Sanyal,S;Dikman,A;Miller,K;Cohen,L;Brooks,A;Wang,Q;Abreu,MT;Aisenberg,J
BackgroundThe basis for individual variation in gastroduodenal vulnerability to NSAIDs is not well understood.AimTo assess whether a gene expression signature is associated with susceptibility to gastroduodenal ulcerations.MethodsTwenty‐fiveHelicobacter pylorinegative adults were treated for 7 days with naproxen 500 mg b.d. Subjects underwent baseline and post‐treatment endoscopy, during which biopsies were taken from antrum and duodenum. RNA extraction and cDNA synthesis were performed, followed by PCR of 23 genes relevant to mucosal injury and repair. Fold changes in gene expression were compared between subjects who developed ulcers and those who did not.ResultsCompared with subjects who did not develop ulcers (n= 18), subjects who developed antral ulcers (n= 7) had significantly greater mucosal up‐regulation of interleukin‐8 [Fold change = 33.5 (S.E.M. = 18.5) vs. −7.7 (3.2)] and of cyclo‐oxygenase‐2 [2.3 (1.7) vs. −10.8 (2.2)]. Conversely, non‐ulcer subjects had significantly greater up‐regulation of toll‐like receptor‐4, cyclo‐oxygenase‐1 and hepatocyte growth factor [14.0 (2.2) vs. −0.8 (1.0), 9.8 (2.4) vs. 0.0 (0.7) and 8.2 (2.6) vs. −2.2 (0.3) respectively].ConclusionsNSAID‐induced antral ulcers are associated with a specific pattern of gastroduodenal mucosal gene expression. These patterns may provide an insight into the molecular basis of individual susceptibility to mucosal injury.
