Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years.
Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years.
复制标题
DOI：
10.1001/jamapsychiatry.2013.2163
复制
发表时间：
2013-12
期刊：
影响因子：
25.8
通讯作者：
Stein, Alan
中科院分区：
文献类型：
--
作者：
Pearson, Rebecca M.;Evans, Jonathan;Kounali, Daphne;Lewis, Glyn;Heron, Jon;Ramchandani, Paul G.;O'Connor, Tom G.;Stein, Alan
一些相对较小的研究表明，母亲产后抑郁症是后代青少年抑郁症的危险因素。然而，没有大型队列研究解决了这个问题。此外，只有一项小型研究调查了产前抑郁症与后代抑郁症之间的关系。了解这些关联对于预防非常重要。研究产前和产后抑郁症与后代抑郁症之间存在独立关联的假设;以及风险途径不同的假设，即与产后抑郁症相关的风险受不利因素（母亲教育程度低）的影响，但与产前抑郁症相关的风险则不受影响。产前和产后父母抑郁症症状与18岁子女抑郁症相关性的前瞻性研究。英国社区出生队列（ALSPAC）。数据来自4,500多名父母及其青少年子女。使用ICD-10诊断18岁的子女重度抑郁症。产后抑郁症是一个独立的危险因素。后代1.28倍（95%CI 1.08至1.51，p=0.003）更可能有抑郁症在18日为每一个s.d增加母亲抑郁症评分产前，独立于后来的母亲抑郁症。产后抑郁症也是母亲受教育程度低的一个危险因素，产后抑郁症评分每增加一个s.d，其后代患抑郁症的可能性增加1.26倍（95%CI 1.06至1.50，p=0.009）。然而，对于受教育程度较高的母亲，几乎没有相关性（OR 1.09，95%CI 0.88至1.36，p=0.420）。适度分析发现，母亲的教育缓和产后抑郁症的影响，但不是产前。父亲抑郁症产前与后代抑郁症，而产后父亲抑郁症表现出类似的模式，母亲抑郁症。研究结果表明，产前治疗母亲抑郁症可以防止后代在成年期抑郁症，并且产后优先考虑较少的母亲可能是最有效的。
Some relatively small studies suggest that maternal postnatal depression is a risk factor for offspring adolescent depression. However no large cohort studies have addressed this issue. Furthermore only one small study has examined the association between antenatal depression and later offspring depression. Understanding these associations is important to inform prevention. To investigate the hypothesis that there are independent associations between antenatal and postnatal depression with offspring depression; and that the risk pathways are different, such that the risk associated with postnatal depression is moderated by disadvantage (low maternal education) but the risk associated with antenatal depression is not. Prospective investigation of associations between symptoms of antenatal and postnatal parental depression with offspring depression at age 18. UK community based birth cohort (ALSPAC). Data from over 4,500 parents and their adolescent offspring. Diagnosis of offspring major depression, aged 18, using ICD-10. Antenatal depression was an independent risk factor. Offspring were 1.28 times (95% CI 1.08 to 1.51, p=0.003) more likely to have depression at 18 for each s.d increase in maternal depression score antenatally, independently of later maternal depression. Postnatal depression was also a risk factor for mothers with low education, with offspring 1.26 times (95% CI 1.06 to 1.50, p=0.009) more likely to have depression for each s.d increase in postnatal depression score. However, for more educated mothers, there was little association (OR 1.09, 95% CI 0.88 to 1.36, p=0.420). Moderation analyses found that maternal education moderated the effects of postnatal but not antenatal depression. Paternal depression antenatally was not associated with offspring depression, while postnatally paternal depression showed a similar pattern to maternal depression. The findings suggest that treating maternal depression antenatally could prevent offspring depression during adulthood and that prioritising less advantaged mothers postnatally may be most effective.
登录
查看更多内容
影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
2.1
作者：
Field, Tiffany
通讯作者：
Field, Tiffany
影响因子：
4.4
作者：
Bell, T;Watson, M;Lewis, G
通讯作者：
Lewis, G
DOI：
10.1097/00004583-200212000-00019
发表时间：
2002-12-01
影响因子：
13.3
作者：
O'Connor, TG;Heron, J;Glover, V
通讯作者：
Glover, V
影响因子：
7.6
作者：
PARKS, PL;SMERIGLIO, VL
通讯作者：
SMERIGLIO, VL