Control of mucin transcription by diverse injury-induced signaling pathways
Control of mucin transcription by diverse injury-induced signaling pathways
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DOI：
10.1164/ajrccm.160.supplement_1.12
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发表时间：
1999-11-01
影响因子：
24.7
通讯作者：
McNamara, N
中科院分区：
文献类型：
--
作者：
Basbaum, C;Lemjabbar, H;McNamara, N
粘蛋白产生是一种进化上古老的防御机制，保留在哺乳动物中，并在所有粘膜表面发挥作用，以保护宿主免受病原体和刺激物的侵害。与低等生物一样，哺乳动物的粘膜（上皮）对不同的损伤产生粘蛋白。我们的研究目的是了解细胞内信号和基因调控机制介导的粘蛋白生产在应对临床上重要的侮辱。迄今为止，我们发现每种类型的侮辱触发的信号通路是不同的。然而，相对常见的是蛋白酪氨酸激酶c-Src、MAP激酶激酶MEK 1/2和转录因子NF-κ B的参与。
Mucin production is an evolutionarily ancient defense mechanism that is retained in mammals and operates at all mucosal surfaces to protect the host against pathogens and irritants. As in lower organisms, the mammalian mucosa (epithelium) produces mucin in response to diverse insults. Our studies aim to understand the intracellular signaling and gene regulation mechanisms mediating mucin production in response to clinically important insults. To date, we find that the signaling pathway triggered by each type of insult is distinct. Relatively common, however, is the involvement of the protein tyrosine kinase c-Src, the MAP kinase kinase MEK 1/2, and the transcription factor NF-kappa B.