Hypothalamic involvement in the regulation of maternal behaviour in the rat: inhibitory roles for the ventromedial hypothalamus and the dorsal/anterior hypothalamic areas.
Hypothalamic involvement in the regulation of maternal behaviour in the rat: inhibitory roles for the ventromedial hypothalamus and the dorsal/anterior hypothalamic areas.
复制标题
下丘脑参与大鼠母性行为的调节：对下丘脑腹内侧和下丘脑背侧/前部区域的抑制作用。
DOI：
10.1046/j.1365-2826.1999.00322.x
复制
发表时间：
1999
影响因子：
3.2
通讯作者：
Coppeta,JS
中科院分区：
文献类型：
--
作者：
Bridges,RS;Mann,PE;Coppeta,JS
本报告研究了下丘脑腹内侧核(VMH)、下丘脑背侧核(DH)和下丘脑前区(AHA)在雌性大鼠母体行为调控中的可能作用。在一系列实验中发现，无论是向VMH注入生理盐水还是降低插管，都会刺激孕酮加雌激素刺激的未分娩大鼠迅速出现母性行为。插管下降到VMH对母亲行为的刺激作用是类固醇依赖的。接下来，在用神经毒素N-甲基-D-天冬氨酸(NMA)对这些区域进行双侧损伤后，检查位于DH/AHA中的细胞体参与母性行为的情况。在接受雌激素治疗的未分娩大鼠中，DH/AHA的NMA损害刺激母体行为的快速发生，而在非类固醇治疗的动物中的NMA损害或在类固醇或非类固醇治疗的大鼠中输注的NMA未能诱导迅速的行为发生。在最后一项研究中，评估了VMH的NMA损伤的影响。与AHA损毁的大鼠一样，VMH的NMA损伤刺激了类固醇刺激的雌性大鼠快速发生母性行为。这些发现表明，VMH和DH/AHA对母性行为的诱导具有慢性类固醇依赖的抑制作用。
The present report examines the possible involvement of the ventromedial hypothalamus (VMH), the dorsal hypothalamus (DH), and the anterior hypothalamic area (AHA) in the regulation of maternal behaviour in the female rat. In a series of experiments it was found that either infusions of saline or lowering cannulas into the VMH stimulated a rapid onset of maternal behaviour in progesterone plus oestrogen‐primed, nulliparous rats. The stimulatory effect of cannula lowering into the VMH on maternal behaviour was shown to be steroid‐dependent. Next, the involvement of cell bodies located in the DH/AHA in maternal behaviour was examined after bilateral lesions of these regions with the neurotoxin, N‐methyl‐d‐aspartic acid (NMA). NMA lesions of the DH/AHA stimulated a rapid onset of maternal behaviour in oestrogen‐treated, nulliparous rats, while NMA lesions in non‐steroid‐treated animals or vehicle infusions in steroid or non‐steroid‐treated rats failed to induce a rapid onset of behaviour. In a final study the effects of NMA lesions of the VMH were evaluated. As in AHA lesioned rats, NMA lesions of the VMH stimulated a fast onset of maternal behaviour in steroid‐primed females. These findings indicate that the VMH as well as the DH/AHA exert chronic steroid‐dependent inhibitory influences on the induction of maternal behaviour.