Desorption Behavior and Distributions of Fluorinated Polymers in MALDI and Electrospray Ionization Mass Spectrometry
Desorption Behavior and Distributions of Fluorinated Polymers in MALDI and Electrospray Ionization Mass Spectrometry
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氟化聚合物在 MALDI 和电喷雾电离质谱中的解吸行为和分布
DOI：
10.1021/ac961136b
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发表时间：
1997
影响因子：
7.4
通讯作者：
R. Cole
中科院分区：
文献类型：
--
作者：
Laurence Latourte;A. Blais;J. Tabet;R. Cole
Matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) have been used to desorb fluorinated polymers for mass spectrometric analyses. Compounds with high fluorine content are insoluble or only sparingly soluble in conventional solvent systems, making them difficult candidates for mass spectrometry studies. Among 11 tested MALDI matrixes, 2,5-dihydroxybenzoic acid produced the highest ion yield for a model fluorinated analyte at a matrix/analyte molar ratio of 1000. Use of this matrix allowed determination of repeat units and the polymer distribution parameters: Mn, Mw, and D. In MALDI, solubility requirements for a fluorinated polymer may be incompatible with those of the matrix, potentially leading to inhomogeneous crystallization which may influence the observed distribution of oligomers. In ESI, when precipitation was not an overriding factor, a minimal aqueous content in the employed solvent vastly improved fluorinated polymer signal intensities compared to purely organ...
