Ultraviolet radiation, evolution and the π-electron system
Ultraviolet radiation, evolution and the π-electron system
复制标题
DOI：
10.1111/j.1095-8312.1998.tb01528.x
复制
发表时间：
1998-03-01
影响因子：
1.9
通讯作者：
Cockell, CS
中科院分区：
文献类型：
--
作者：
Cockell, CS
紫外线辐射是一种重要的天然诱变剂。由于能量特性，最容易受到紫外线吸收的碳化合物是那些含有π电子系统的碳化合物。 π电子构型最常见于有机化学中的芳环结构中。对一系列重要生化过程的分析表明，该系统的敏感性是几乎所有紫外线辐射对生命影响的核心。它的破坏导致了紫外线辐射引起的核酸、蛋白质和脂质损伤。然而，在整个生物圈的进化过程中，生命也利用含有π电子的化合物的紫外线吸收来屏蔽紫外线辐射，将其紫外线吸收转化为一种保护机制。虽然紫外线辐射效应可以从生物体生理学的角度进行分析，但更还原论的分析表明，π电子系统是生物体中紫外线辐射损伤效应和保护策略进化的常见化学决定因素。它揭示了一个有趣的进化故事。 (C) 1998 伦敦林奈学会。
Ultraviolet radiation is an important natural mutagen. Because of the energetic characteristics, the carbon compounds most susceptible to UV absorbance are those that contain pi-electron systems. The pi-electron configuration is most commonly represented in organic chemistry within aromatic ring structures. An analysis of a wide range of biochemically important processes shows that the susceptibility of this system lies at the heart of almost all UV radiation effects on life. Its disruption accounts for UV radiation-induced damage in nucleic acids, proteins and lipids. However, throughout the evolution of the biosphere, life has also used the UV absorbance of pi-electron containing compounds to screen out UV radiation, turning their UV absorbance into a protection mechanism. Although UV radiation effects can be analyzed in terms of organism physiology, a more reductionist analysis shows the pi-electron system to be the common chemical determinant in the evolution of UV radiation damage effects and protection strategies in organisms. It reveals an interesting evolutionary story. (C) 1998 The Linnean Society of London.