HIV AND T-CELL EXPANSION IN SPLENIC WHITE PULPS IS ACCOMPANIED BY INFILTRATION OF HIV-SPECIFIC CYTOTOXIC T-LYMPHOCYTES
HIV AND T-CELL EXPANSION IN SPLENIC WHITE PULPS IS ACCOMPANIED BY INFILTRATION OF HIV-SPECIFIC CYTOTOXIC T-LYMPHOCYTES
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DOI：
10.1016/0092-8674(94)90417-0
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发表时间：
1994-08-12
期刊：
影响因子：
64.5
通讯作者：
WAINHOBSON, S
中科院分区：
文献类型：
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作者：
CHEYNIER, R;HENRICHWARK, S;WAINHOBSON, S
人类免疫缺陷病毒（HIV）的复制和T细胞增殖进行了研究，在原位的PCR为基础的分析个人显微解剖脾白色髓。HIV基因型和T细胞的精确区室化揭示了创始人效应，表明潜伏感染的CD4（+）T细胞通过高度局部化的抗原呈递而不是CD4（+）T淋巴母细胞被血液传播病毒或免疫复合物感染。HIV感染的白色牙髓可被HIV特异性细胞毒性T淋巴细胞浸润，从而暗示它们参与体内CD4（+）T细胞的破坏。这些数据一起描述了抗原驱动的T细胞募集和激活以及HIV复制和传播的迭代和有害机制，从而破坏了新感染的细胞。
Human immunodeficiency virus (HIV) replication and T cell proliferation were investigated in situ by a PCR-based analysis of individual microdissected splenic white pulps. Founder effects, revealed by an exquisite compartmentalization of HIV genotypes and T cells, indicated the recruitment of latently infected CD4(+) T cells through highly localized antigen presentation rather than the infection of CD4(+) T lymphoblasts by blood-borne virus or immune complexes. HIV-infected white pulps could be Infiltrated by HIV-specific cytotoxic T lymphocytes, thereby implicating them in CD4(+) T cell destruction in vivo. Together these data describe an iterative and deleterious mechanism of antigen-driven T cell recruitment and activation, as well as HIV replication and spread, with consequent destruction of the newly infected cells.